sh-Polypeptide-12 is a synthetic recombinant single-chain peptide, an analog of human Interleukin 4 (IL-4), that acts as an antihistamine or immune-suppressor agent to reduce scratching by inhibiting the autoimmune response.
Peptides
There are numerous examples in physiology of peptide regulatory elements that play integral roles in basic homeostatic mechanisms such as injury-repair responses and other stimulus-response actions. Among these are well-known neuropeptides (e.g., bradykinins, endorphins); metabolism and fat storage regulators (e.g., neuropeptide Y, leptin, insulin); tanning and skin pigmentation-related peptides (e.g., α-MSH, ACTH, Agouti), and peptides involved in wound healing (e.g., FGF).
This large group of innovative cosmeceutical ingredients triumphed in the world of skincare products during the last two decades. Peptides are chains of amino acids that are attached in a specific order. Amino acids are naturally occurring in the body and are vital to everyday living processes. Peptides can be made up of 2 or more amino acids that can stimulate different responses within the body. As a result, peptides serve as tiny messengers that can be sent to kick the skin into gear and make it look better.
Peptides are leading a beauty revolution due to their excellent multi-functional properties; formularies are scrambling to access the latest advances in cosmetic peptide technology. In addition, their "Botox-like" performance, activation of collagen and elastin production, and skin-lightening effect make them very efficient against coarse wrinkles and hyperpigmentation of the skin.
sh-Polypeptide-121 is a synthetic single-chain recombinant peptide derived from human collagen type 21 (also called collagen alpha-1 and encoded by the COL21A1 gene). It is known under the trade name HumaColl™21.
sh-Polypeptide-19 (former rh-Oligopeptide-3 and rh-Polypeptide-19) is a synthetic single-chain recombinant peptide, an analog of human TGF-α (Transforming Growth Factor-α).
sh-Polypeptide-2 is a synthetic recombinant analog of human Thioredoxin (TRX) that stimulates dermal cell growth and proliferation and protects them from oxidative stress.
sh-Polypeptide-22 is a synthetic recombinant human transforming growth factor beta 1 (TGFβ-1) analog peptide composed of 113 amino acids.
Besides lactation, human Prolactin is a hormone that regulates hair follicle cycles, angiogenesis, keratinocyte proliferation, and the activity of epithelial stem cells.
sh-Polypeptide-3 (former rh-Oligopeptide-5) is a single-chain synthetic recombinant peptide, an analog of human KGF (Keratinocyte Growth Factor). KGF was first described in 1989 as a human growth factor that stimulated epithelial cell proliferation.
sh-Polypeptide-31 is a synthetic recombinant peptide that mimics human Insulin-like Growth Factor-2 (IGF-2). The old designation was rh-Polypeptide-31 (rh- prefix means recombinant human).
sh-Polypeptide-4 is a synthetic recombinant analog of human SCF (Stem Cell Factor, Mast Cell Growth Factor, or Kit ligand), a peptide of up to 273 amino acids.
sh-Polypeptide-40 is a synthetic recombinant human placental lactogen (hPL) hormone analog peptide composed of 192 amino acids. hPL is also known as human chorionic somatomammotropin (hCS) or human chorionic somatotropin.
sh-Polypeptide-5 is a synthetic recombinant peptide, an analog of human TGFβ3 (Transforming Growth Factor β3).
sh-Polypeptide-50 is a single-chain synthetic recombinant peptide that repeats the amino acid sequence of Tropoelastin, a protein produced inside fibroblasts.
sh-Polypeptide-6 is a synthetic recombinant single-chain peptide, an analog of human Interleukin 10 (IL-10). Interleukin 10 is an anti-inflammatory cytokine that regulates the immune response and antibody production.
sh-Polypeptide-62 is a synthetic recombinant peptide, an analog of human Hepatocyte Growth Factor (HGF). It stimulates keratin production, hair growth, and hair pigmentation, and accelerates wound healing and skin regeneration.
sh-Polypeptide-64 is a synthetic recombinant peptide derived from the human Aquaporin-1 (AQP-1) protein that promotes the transport of water across biological membranes.
sh-Polypeptide-7 is a synthetic recombinant analog of human growth hormone (hGH), also called Somatotropin.
sh-Polypeptide-71 (former sh-Polypeptide-65) is a synthetic recombinant human Vasoactive Intestinal Peptide or VIP composed of up to 170 amino acids.
sh-Polypeptide-8 is a synthetic single-chain recombinant analog of human PDGF (Platelet-Derived Growth Factor) that is involved in normal skin growth, healing, and wound repair. rh-PDGF mimics the biological activity of the endogenous protein and is th
sh-Polypeptide-9 is a synthetic recombinant analog of human VEGFA (Vascular Endothelial Growth Factor A). It enhances cell division and migration by increasing the permeability of capillary vessels to serum proteins.
sh-Polypeptide-93 is a synthetic recombinant human connective tissue growth factor (CTGF) analog peptide composed of 324 amino acids.
Shield Bact is a Cationic Host Defense Peptide (CHDP), a hexapeptide with antimicrobial action.
Several factors are involved in skin aging, such as molecular mechanisms related to collagen and elastin proteins degradation, and lipid content in the skin.
sr-(Spider Polypeptide-1 Oligopeptide-178) is a single-chain recombinant polypeptide that repeats a part of spider silk protein. It is a white, soft powder produced by fermentation with gene-modified yeast in a nutrient-rich medium.
sr-Clostridium Botulinum Polypeptide-1 is a protein toxin (1296 amino acids in length) derived from the fermentation of Clostridium botulinum bacteria, was historically used as a medical treatment for localized movement disorders such as blepharospasm
Syn-Ake - immediate smoothing of the skin, thanks to a remodeled tripeptide, originally derived from snake poison, Waglerin-1, which reduces muscle contractions by up to 80 % (in-vitro results), owing to the disabling of the mnACh-receptor.
Syn®-Hycan is an innovative peptide (tripeptide) based complex developed to reduce visible signs of skin aging. It leaves a dual effect.
Syn®-Coll (Palmitoyl Tripeptide-5) is a patented lipo-tripeptide-based complex based on many years of experience synthesizing peptides for the pharmaceutical industry.
Tetracarboxymethyl Hexanoyl Dipeptide-12 is a synthetic peptide derivative that enhances the expression of genes responsible for adiponectin production while inducing dermal cells' protective autophagy.
Tetrapeptide-21 (GEKG-peptide) is a synthetic peptide that repeats a part of a sequence (Gly-Glu-Lys-Gly) of several extracellular matrix (ECM) proteins, such as collagens I, II, III, IV, V, elastin, and pro-elastin.