sh-Polypeptide-31 is a synthetic recombinant peptide that mimics human Insulin-like Growth Factor-2 (IGF-2). The old designation was rh-Polypeptide-31 (rh- prefix means recombinant human). IGF-II promotes the proliferation and migration of dermal fibroblasts and enhances collagen production.
Binding to skin cell membrane receptors, sh-Polypeptide-31 has an insulin-like effect. It promotes dynamic restoration of the structure of all skin layers. It strengthens intercellular connections and thickens the skin. Insulin-like Growth Factor-1 (IGF-1; sh-Oligopeptide-2) is responsible for “tissue memory” - preserving the original parameters of the structure, quality, and properties of the skin given by nature.
Incorporated in skincare preparations, sh-Polypeptide-31 reduces wrinkles, increases skin density, and tightens it. In hair care applications, IGF-2 stimulates growth and limits hair loss. In body contouring products, sh-Polypeptide-31 induces lipolysis by activating adenylate cyclase, which breaks down adipocyte triglycerides into fatty acids.
Due to mitogen and growth factor-mimicking activity, products containing sh-Polypeptide-31 should be used strictly according to instructions or after physician consultation, as overexpression of IGF-2 correlates with hypertrophic scar formation in damaged skin and tumor progression.
Decapeptide-4 is a synthetic peptide known under the trade name CG-IDP2 that mimics the Somatomedin C (IGF-1) growth factor involved in normal skin growth, healing, and wound repair.
sh-Oligopeptide-2 is a synthetic single-chain (7.6 kDa) polypeptide hormone analog structurally similar to proinsulin, an Insulin-like Growth Factor (IGF-1) naturally synthesized by fibroblast cells.
sh-Polypeptide-10 is a synthetic recombinant single-chain peptide, an analog of human Fibroblast Growth Factor 10 (FGF10) that is involved in normal skin growth, regeneration, and wound repair.
sh-Polypeptide-71 (former sh-Polypeptide-65) is a synthetic recombinant human Vasoactive Intestinal Peptide or VIP composed of up to 170 amino acids. This biologically active peptide regulates vasodilation in skin tissue, soothes inflammation, and enhances angiogenesis.
sh-Polypeptide-3 (former rh-Oligopeptide-5) is a single-chain synthetic recombinant peptide, an analog of human KGF (Keratinocyte Growth Factor). KGF was first described in 1989 as a human growth factor that stimulated epithelial cell proliferation.
sh-Oligopeptide-4 is a synthetic recombinant Thymosin-β4 peptide that helps strengthen hair while stimulating hair follicles to produce healthier hair.
sh-Polypeptide-93 is a synthetic recombinant human connective tissue growth factor (CTGF) analog peptide composed of 324 amino acids. It mimics the Insulin-like Growth Factor (IGF)-binding domain of CTGF and regulates the expression of genes responsible for collagen production in fibroblasts.
Oligopeptide-55 is a synthetic 12 amino acid long peptide that boosts keratinocytes and fibroblasts proliferation and collagen and elastin production improving skin elasticity and resilience. This peptide is also known under the trade name CG-Collagrin.
Decapeptide-10 is a synthetic peptide that boosts the generation of new dermal cells lessening the appearance of fine lines and wrinkles, preventing their formation, and strengthening hair follicles. This peptide is also known under the trade name CG-Keramin2.
Myristoyl Pentapeptide-4 (formerly Myristoyl Pentapeptide-3) is a synthetic lipo-peptide sold under the trade name Collasyn 514KS, an ester of Myristic acid (attached to the N-terminus) and KTTKS peptide with sequence Myr-Lys-Thr-Thr-Lys-Ser.
Palmitoyl sh-Tripeptide-3 Amide is a low molecular weight lipo-peptide derived from Pro-Epidermal Growth Factor (EGF; sequence position 894-896) that stimulates cell growth, proliferation, and differentiation by binding to its receptor EGFR.
sh-Polypeptide-8 is a synthetic single-chain recombinant analog of human PDGF (Platelet-Derived Growth Factor) that is involved in normal skin growth, healing, and wound repair. rh-PDGF mimics the biological activity of the endogenous protein and is the active ingredient in several FDA-appro
