Peptides
There are numerous examples in physiology of peptide regulatory elements that play integral roles in basic homeostatic mechanisms such as injury-repair responses and other stimulus-response actions. Among these are well-known neuropeptides (e.g., bradykinins, endorphins); metabolism and fat storage regulators (e.g., neuropeptide Y, leptin, insulin); tanning and skin pigmentation-related peptides (e.g., α-MSH, ACTH, Agouti), and peptides involved in wound healing (e.g., FGF).
This large group of innovative cosmeceutical ingredients triumphed in the world of skincare products during the last two decades. Peptides are chains of amino acids that are attached in a specific order. Amino acids are naturally occurring in the body and are vital to everyday living processes. Peptides can be made up of 2 or more amino acids that can stimulate different responses within the body. As a result, peptides serve as tiny messengers that can be sent to kick the skin into gear and make it look better.
Peptides are leading a beauty revolution due to their excellent multi-functional properties; formularies are scrambling to access the latest advances in cosmetic peptide technology. In addition, their "Botox-like" performance, activation of collagen and elastin production, and skin-lightening effect make them very efficient against coarse wrinkles and hyperpigmentation of the skin.
Acetyl Hexapeptide-38 is a synthetic peptide (with sequence Ac-Ser-Val-Val-Val-Arg-Thr-NH2) found with screening methods and using the reporter gene assay from millions of other hexapeptides with different
The skin is facing many kinds of stress, such as aging, mycobacterium and virus attack, UV and infrared light, and recently issued environmental stress, such as pollen, PM2.5, and PM10, including its harmful components polycyclic aromatic hydrocarbons (PAHs) and heavy metals.
Biotinoyl Hexapeptide-2 Amide is a conjugate of Hexapeptide-2 and biotin (vitamin B7), providing a synergic effect of those superstar ingredients. It is known under the trade name Biotide2000.
Cyclohexpeptide-90 is a synthetic cyclic hexapeptide that increases BiP and Calreticulin protein production, chaperones in the endoplasmic reticulum responsible for proteins properly folding. This peptide is known under the trade name Poptide™.
It is well known that skin pigmentation is mainly affected by three major signaling pathways; α-MSH/MC-1R, ET-1/ETBR, and SCF/c-kit.
Hexacarboxymethyl Dipeptide-12 is a peptide derivative that acts as a direct activator of Sirtuin1 (SIRT1). SIRT1 is an NAD+-dependent deacetylase enzyme that regulates cellular metabolism, survival, and lifespan. It deacetylates the target protein FoxO1, initiating cell autophagy.
Hexapeptide-94 Gamma Dipeptide-4 is a synthetic octapeptide with the sequence H-Arg-Leu-Arg-Trp-Arg-γ-Glu-Cys-Gly-OH. It is also known under the trade name Whitening peptide-1.
Palmitoyl Dipeptide-17 (Palmitoyl Glycylproline) is a synthetic lipopeptide with the sequence Pal-Gly-Pro. It is known under the trade name Proliphil.
It has been well documented that extracts from yeast fermentation, particularly Saccharomyces cerevisiae, have demonstrated wound-healing properties.
Tetracarboxymethyl Hexanoyl Dipeptide-12 is a synthetic peptide derivative that enhances the expression of genes responsible for adiponectin production while inducing dermal cells' protective autophagy. It is also known under the trade name AdipoSOL™ 2000.
Many eukaryotic microorganisms, like Saccharomyces cerevisiae, developed protective mechanisms in response to environmental damaging factors like UV exposure, temperature changes (excess heat or freezing), or oxidative agents like ozone.