Acetyl Hexapeptide-38 is a synthetic peptide (with the sequence Ac-Ser-Val-Val-Val-Arg-Thr-NH2) identified through screening methods using a reporter gene assay of millions of other hexapeptides with different sequences. It is also known by the trade name Adifyline®.
According to the manufacturer, Acetyl Hexapeptide-38 increases PGC-1α (Peroxisome proliferator-activated receptor gamma coactivator 1α) expression by 61.1%, which plays an essential role in cellular energy metabolism and enhances lipid storage capacity in healthy, mature adipocytes (fatty cells) in white adipose tissue. In addition, it increases adipocyte differentiation from subcutaneous preadipocytes, enhancing lipid accumulation.
The ability to increase fatty tissue volume beneath the skin in specific areas makes Acetyl Hexapeptide-38 an intriguing ingredient for skin and body care applications, helping reshape and remodel problematic areas, including the facial oval, breasts, and buttocks. It smooths expression lines and wrinkles by increasing the skin's volume, revealing a lifted, supple, and youthful appearance.
In body care preparations, it increases the volume of specific areas, such as the breasts or buttocks, where a replenishing effect is desired, delivering attractive body curves. Acetyl Hexapeptide-38 is used in facial redefining preparations, breast-firming formulations, facial anti-aging products, makeup for mature women, lip care products, and specific formulations for the cleavage area (mature women). In addition, it can be found in anti-aging hand products, which lose adipose tissue with age.
