Hexapeptide-33

Functions
Microcirculation enhancer
Skin whitening agent
Smoothing
Regeneration booster
Antioxidant
Protective
CAS Number(s)
1114970-34-1
INCI name
Hexapeptide-33
Origin
Synthetic

Hexapeptide-33 is a biologically active peptide with the sequence Ser-Phe-Lys-Leu-Arg-Tyr-NH2 (SFKLRY) that stimulates blood vessel formation, known under the trade name W3 peptide. It was developed by Novacell Technology (NCP901) using peptide library technology.

Hexapeptide-33 targets G-Protein-Coupled-Receptors (GPCR) widely distributed in human body cells. Novel studies showed that a subtype of the GPCR family, the Adhesion G-Protein-Coupled Receptor (aGPCR), is expressed in skin keratinocytes and is involved in epidermal differentiation.

The manufacturer claims a triple beneficial effect starting with "W":

  1. Whitening,
  2. Wrinkle-smoothing,
  3. Wound-repair.

Hexapeptide-33 is used in many anti-aging products, including facial creams, masks, and treatments. The safety assessment of the peptide showed that it is not irritating at the concentrations used in cosmetics and is well tolerated by the skin.
Synonyms
W3 PEPTIDE
Angio-S
SFKLRY peptide
Ser-Phe-Lys-Leu-Arg-Tyr-NH2
Changed

References

Identification of novel synthetic peptide showing angiogenic activity in human endothelial cells
Author(s):
, , , , ,
PMID:
18992291
DOI:
10.1016/j.peptides.2008.10.003
The Safety Evaluation of a Potent Angiogenic Activator, Synthetic Peptide (SFKLRY-NH2) for the Skin Application
Author(s):
, , , , , , ,
PMID:
24278589
DOI:
10.5487/TR.2012.28.1.051