sh-Polypeptide-7 is a synthetic recombinant analog of human growth hormone (hGH), also called Somatotropin. It repeats the amino acid sequences of hGH and mimics its action, stimulating the growth, reproduction, and regeneration of skin cells.
Recombinant Somatotropin is used in medicine to accelerate the healing of extensive wounds of different origins, burns, injuries, and donor sites after autotransplantation. It is also used to treat skin photoaging and other conditions where reepithelialization, angiogenesis, and extracellular matrix components deposition are crucial.
In the skin, sh-Polypeptide-7 binds to the growth hormone receptor (GHR) on fibroblasts, enhancing their proliferation and enhancing the production of insulin‑like growth factor‑1 (IGF‑1) and its binding protein IGFBP‑3. IGF‑1 acts synergistically with rh-hGH, enhancing collagen and other extracellular matrix components production.
In skin care applications, sh-polypeptide-7 helps to reduce the appearance of fine lines and wrinkles, promoting cell vitality and exposing a youthful, healthy, and refreshed appearance. In hair care preparations, it promotes hair growth and development, strengthening and stimulating follicles.
