sh-Oligopeptide-2 is a synthetic single-chain (7.6 kDa) polypeptide hormone analog structurally similar to proinsulin, an Insulin-like Growth Factor (IGF-1) naturally synthesized by fibroblast cells. It is a growth hormone involved in the formation of bone, muscle, and nerve tissues, and it improves the regeneration of damaged cells by building new blood vessels for cells that are reduced in damaged or aged skin.
sh-Oligopeptide-2 forms blood vessels from degenerated cells as they age, enabling them to replace accumulated CO2 and waste products and revitalize aged cells into young cells. It improves GH and other hormone secretion by providing IGF-1 directly and supports the standard insulin-resistance action.
sh-Oligopeptide-2 activates cellular signaling in the AKT pathway, which plays an essential role in preventing aging. It promotes regeneration and accelerates wound healing. In the scalp, it promotes follicle development and helps increase hair thickness.
Applied topically, sh-Oligopeptide-2 enhances the biosynthesis of Hyaluronic acid and other extracellular matrix (ECM) components, resulting in a smoother, more youthful, and healthier appearance. It minimizes the appearance of fine lines and deep wrinkles and reduces blotchiness.
Thanks to its anabolic fat-burning effect, sh-Oligopeptide-2 effectively refines skin texture and glides, while slimming the face and body. It also strengthens hair by boosting primary hair cell proliferation and stimulating hair follicles to produce a stronger hair shaft. It is used in many high-end modern anti-aging products and superstar complex ingredients, such as Bio Placenta.
However, any growth factor-mimicking peptide should be used with caution, as GFs are correlated with tumorigenesis or progression. Recombinant IGF-1 correlated with Melanoma progression.
Expression of Growth Hormone Receptor, Insulin-Like Growth Factor 1 (IGF-1) and IGF-1 Receptor mRNA and Proteins in Human Skin
Author(s):
Tavakkol Amir., Elder James T, Griffiths Christopher E M, Cooper Kevin D, Talwar Harvinder., Fisher Gary J, Keane Karen M, Foltin Susan K, Voorhees John J
DOI:
10.1111/1523-1747.ep12616668
Insulin-like growth factor-I in wound healing of rat skin
Decapeptide-4 is a synthetic peptide known under the trade name CG-IDP2 that mimics the Somatomedin C (IGF-1) growth factor involved in normal skin growth, healing, and wound repair.
Oligopeptide-24 (formerly Oligopeptide-23; known under the trade name CG-EDP3) is a synthetic biomimetic peptide that stimulates skin cell proliferation by up-regulation of EGF (Epidermal Growth Factor) expression.
sh-Polypeptide-7 is a synthetic recombinant analog of human growth hormone (hGH), also called Somatotropin. It repeats the amino acid sequences of hGH and mimics its action, stimulating the growth, reproduction, and regeneration of skin cells.
Palmitoyl sh-Tripeptide-3 Amide is a low molecular weight lipo-peptide derived from Pro-Epidermal Growth Factor (EGF; sequence position 894-896) that stimulates cell growth, proliferation, and differentiation by binding to its receptor EGFR.
Myristoyl Nonapeptide-3 is a synthetic biomimetic lipo-peptide with retinol-like action, known under the trade name RetinoPeptide™ 189. Mimicking famous anti-aging vitamin A's biological activity boosts collagen type I production, exposing a firmer, smoother, and youthful appearance.
sh-Oligopeptide-4 is a synthetic recombinant Thymosin-β4 peptide that helps strengthen hair while stimulating hair follicles to produce healthier hair.
sh-Polypeptide-1 is a single-chain synthetic peptide (molecular weight 17.25 kDa) analog of bFGF (basic Fibroblast Growth Factor or FGF2), that regulates skin renewal promotion.
sh-Polypeptide-10 is a synthetic recombinant single-chain peptide, an analog of human Fibroblast Growth Factor 10 (FGF10) that is involved in normal skin growth, regeneration, and wound repair.
Bis(Tripeptide-1) Copper Acetate is a copper-containing complex of Tripeptide-1 acetate, a derivative of the famous GHK peptide (Glycyl-L-Histidyl-L-Lysine). Its solution is a clear blueish liquid. Its color results from the presence of copper ions.
Although hair disorders are not life-threatening, their profound impact on social interaction and on patients' psychological aspects is undeniable. The demand for hair loss treatment has led to a multibillion-dollar industry.
