Authored by: Arthur Ghochikyan, M.D.
Functions
Anti-aging
Regeneration booster
Smoothing
Hair growth stimulator
INCI nameSh-Polypeptide-3
sh-Polypeptide-3 (former rh-Oligopeptide-5) is a single-chain synthetic recombinant peptide, an analog of human KGF (Keratinocyte Growth Factor). KGF was first described in 1989 as a human growth factor that stimulated epithelial cell proliferation.
sh-Polypeptide-3 affects the proliferation and differentiation of various cell types, as it is a part of the heparin-binding fibroblast growth factor (FGF) superfamily, FGF7. KGF is involved in early hair growth as an essential go-between.
sh-Polypeptide-3 promotes dermal cell adhesion, spreading, and proliferation, and boosts regenerative processes in the skin and wound healing. It is an essential mediator in epithelial repairs and mesenchymal interactions. It is used in medicine to treat the adverse effects of radiotherapy on the skin or the oral cavity.
In addition, sh-Polypeptide-3 strengthens hair follicles, stimulating hair growth and enhancing their mechanical properties, health, and appearance. The former designation was rh-Polypeptide-3 (rh- prefix means recombinant human).
Synonyms
Recombinant Human Keratinocyte Growth Factor
CG-KGF
rh-Polypeptide-3
Human Oligopeptide-5
rh-Oligopeptide-5
Fibroblast Growth Factor 7
Palifermin
References
Keratinocyte growth factor
Author(s):
Rubin JS, Bottaro DP, Chedid M, Miki T, Ron D, Cheon G, Taylor WG, Fortney E, Sakata H, Finch PW
DOI:
10.1006/cbir.1995.1085
Effect of tumour-cell-derived or recombinant keratinocyte growth factor (KGF) on proliferation and radioresponse of human epithelial tumour cells (HNSCC) and normal keratinocytes in vitro
Author(s):
Hille A, Grüger S, Christiansen H, Wolff HA, Volkmer B, Lehmann J, Dörr W, Rave-Fränk M
DOI:
10.1007/s00411-010-0271-7
Palifermin: in myelotoxic therapy-induced oral mucositis
Author(s):
Siddiqui MA, Wellington K
DOI:
10.2165/00003495-200565150-00008
Non-viral liposomal keratinocyte growth factor (KGF) cDNA gene transfer improves dermal and epidermal regeneration through stimulation of epithelial and mesenchymal factors
Author(s):
Jeschke MG, Richter G, Höfstädter F, Herndon DN, Perez-Polo JR, Jauch KW
DOI:
10.1038/sj.gt.3301732
Keratinocyte growth factor induces hyperproliferation and delays differentiation in a skin equivalent model system
Author(s):
Andreadis ST, Hamoen KE, Yarmush ML, Morgan JR
DOI:
10.1096/fj.00-0324com
Modulation of keratinocyte growth factor and its receptor in reepithelializing human skin
Author(s):
Marchese C, Chedid M, Dirsch OR, Csaky KG, Santanelli F, Latini C, LaRochelle WJ, Torrisi MR, Aaronson SA
DOI:
10.1084/jem.182.5.1369
