sh-Polypeptide-3 (former rh-Oligopeptide-5) is a single-chain synthetic recombinant peptide, an analog of human KGF (Keratinocyte Growth Factor). KGF was first described in 1989 as a human growth factor that stimulated epithelial cell proliferation.
sh-Polypeptide-3 affects the proliferation and differentiation of various cell types, as it is a part of the heparin-binding fibroblast growth factor (FGF) superfamily, FGF7. KGF is involved in early hair growth as an essential go-between.
sh-Polypeptide-3 promotes dermal cell adhesion, spreading, and proliferation, and boosts regenerative processes in the skin and wound healing. It is an essential mediator in epithelial repairs and mesenchymal interactions. It is used in medicine to treat the adverse effects of radiotherapy on the skin or the oral cavity.
In addition, sh-Polypeptide-3 strengthens hair follicles, stimulating hair growth and enhancing their mechanical properties, health, and appearance. The former designation was rh-Polypeptide-3 (rh- prefix means recombinant human).
Synonyms
Recombinant Human Keratinocyte Growth Factor
CG-KGF
rh-Polypeptide-3
Human Oligopeptide-5
rh-Oligopeptide-5
Fibroblast Growth Factor 7
Palifermin
Changed
References
Keratinocyte growth factor
Author(s):
Rubin JS, Bottaro DP, Chedid M, Miki T, Ron D, Cheon G, Taylor WG, Fortney E, Sakata H, Finch PW
PMID:
7640656
DOI:
10.1006/cbir.1995.1085
Effect of tumour-cell-derived or recombinant keratinocyte growth factor (KGF) on proliferation and radioresponse of human epithelial tumour cells (HNSCC) and normal keratinocytes in vitro
Author(s):
Hille A, Grüger S, Christiansen H, Wolff HA, Volkmer B, Lehmann J, Dörr W, Rave-Fränk M
PMID:
20213138
DOI:
10.1007/s00411-010-0271-7
Palifermin: in myelotoxic therapy-induced oral mucositis
Author(s):
Siddiqui MA, Wellington K
PMID:
16225371
DOI:
10.2165/00003495-200565150-00008
Non-viral liposomal keratinocyte growth factor (KGF) cDNA gene transfer improves dermal and epidermal regeneration through stimulation of epithelial and mesenchymal factors
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