Functions
Anti-aging
Firming
Smoothing
Regeneration booster
INCI name
Sh-Polypeptide-93
Origin
Synthetic
sh-Polypeptide-93 is a synthetic recombinant human connective tissue growth factor (CTGF) analog peptide composed of 324 amino acids. It mimics the Insulin-like Growth Factor (IGF)-binding domain of CTGF and regulates the expression of genes responsible for collagen production in fibroblasts.
CTGF expression levels are reduced in aged human skin, so the topical application of sh-Polypeptide-93 mimics the growth factor's action, boosting collagen production, improving skin elasticity, and increasing dermal thickness.
sh-Polypeptide-93 is a safe and effective ingredient for anti-aging skin care applications, with skin-firming, anti-wrinkle, and wound-healing properties.
Synonyms
Clairesome-CT
Insulin-Like Growth Factor-Binding Protein 8
Changed
References
Recombinant connective tissue growth factor modulates porcine skin fibroblast gene expression
PMID:
12753604
DOI:
10.1046/j.1524-475x.2003.11311.x
A physiological role for connective tissue growth factor in early wound healing
PMID:
23212098
DOI:
10.1038/labinvest.2012.162
Connective tissue growth factor siRNA modulates mRNA levels for a subset of molecules in normal and TGF-beta 1-stimulated porcine skin fibroblasts
PMID:
15086772
DOI:
10.1111/j.1067-1927.2004.012113.x
Topically applied connective tissue growth factor/CCN2 improves diabetic preclinical cutaneous wound healing: potential role for CTGF in human diabetic foot ulcer healing
PMID:
25789327
DOI:
10.1155/2015/236238
Effect of small interfering RNA on the expression of connective tissue growth factor and type I and III collagen in skin fibroblasts of patients with systemic sclerosis
PMID:
17107381
DOI:
10.1111/j.1365-2133.2006.07438.x
