Acetyl sh-Hexapeptide-5 Amide Acetate is a synthetic matrikine peptide with sequence Ac-Pro‑Pro‑Pro‑Asp‑Ser‑Arg-NH2 (PPPDSR), derived from Versican proteoglycan (glycosylated protein). It is also known under the trade name Versillin™.
Versican is a structural macromolecule in the extracellular matrix (ECM) of many human tissues and organs, including skin, where it performs many functions. Versican binds and interacts with HA, fibrillin-1, and fibronectin, improving water retention, microfibril connection and organization, and regulating collagen fibrillogenesis and fibril assembly within the fibers. It is involved in cell adhesion, proliferation, and migration, and plays an essential role in tissue development and maintenance.
According to the manufacturer, Acetyl sh-Hexapeptide-5 amide acetate is a biomimetic of Versican (its sequence corresponds to the N-terminal region of Versican, residues 334-339). Preventing elastin degradation (inhibiting elastase and the production of metalloproteinases 1 and 3), it promotes the production and assembly of tropoelastin, hyaluronic acid, and other ECM components, improving the skin's viscoelasticity in a complex, enhancing volume, elasticity, and flexibility. Acetyl sh-Hexapeptide-5 amide acetate remodels the skin, strengthens cohesion, and improves firmness.
Acetyl sh-Hexapeptide-5 Amide Acetate promotes the fibrillin-versican-hyaluronic acid complex formation, reinforcing skin ligaments, their anchoring, and moving ligaments into the original position (repositioning). This peptide-based ingredient is safe and suitable for all types of anti-aging formulations.
