sh-Polypeptide-121 is a synthetic single-chain recombinant peptide derived from human collagen type 21 (also called collagen alpha-1 and encoded by the COL21A1 gene). It is known under the trade name HumaColl™21.
Structurally, sh-Polypeptide-121 contains amino acid triplets starting with glycine, and the most often occurring triplet (about 10.5%) is a Gly-Pro-Hyp, which is a well-known sequence and individually is a biomimetic peptide (Tripeptide-29) that enhances natural collagen production in the skin, reducing wrinkles, firming, and improving elasticity.
According to the manufacturer's claim, besides wrinkle reduction, sh-Polypeptide-121 also effectively fights against erythema, and improves hydration and skin tone. Stimulating fibroblasts, it boosts collagen, elastin, and hyaluronic acid production.
In addition, sh-Polypeptide-121 improves the skin's tactile and visual texture, exposing a smoother, youthful, and radiant appearance. Incorporated in skincare preparations, it showed excellent skin compatibility, safety, and effectiveness, and is used in many high-end anti-aging products.
