Acetyl Tripeptide-30 Citrulline is a synthetic peptide that prevents the degradation of extracellular matrix components through the inhibition of MMP (metalloproteinase) enzymes. It has the sequence Ac-Arg-His-His-Cit.
An In Vitro study was conducted to evaluate the inhibition of metalloproteinases (MMPs) by Acetyl Tripeptide-30 Citrulline. It has been tested with several metalloproteinases to assess the peptide's selectivity and effectiveness against MMPs. An Inhibition of MMP activity was calculated using fluorescence released by gelatin (denatured collagen).
Results revealed that Acetyl Tripeptide-30 Citrulline completely inhibits MMP-2 activity, which is responsible for the degradation of type I collagen fibers, the most abundant type of collagen in the dermis. It has also been shown to inhibit the activity of MMP-9 by 63.1%, and MMP-1 and MMP-3 by 35% to 40%. A volunteer trial showed noticeable anti-aging effects and a visible reduction in stretch marks.
Recent studies reveal that Acetyl Tripeptide-30 Citrulline has anti-inflammatory and antioxidant properties. It also enhances Collagen type IV production and the important proteins Transglutaminase 1 and Filaggrin, which are involved in skin barrier function. Moreover, it also increases Aquaporin 3 production, improving skin hydration.Preserving skin's structural proteins and extracellular matrix (ECM) components, Acetyl Tripeptide-30 Citrulline leaves a significant firming, lifting, and anti-aging effect. Incorporated into high-end skincare products and peptide-based complexes like Vanistryl®, it enhances ECM component regeneration, revealing a supple, youthful, and smoother skin appearance.
We sincerely apologize for the error previously published on our website regarding the amino acid sequence of Acetyl Tripeptide-30 Citrulline mentioned as Peptide AC29. The sequence listed as
Lys-α-Asp-Ile-Citrullineand namePeptide AC29were incorrect.Accuracy and transparency are central to our commitment, and we regret any confusion this may have caused. We have corrected the information to ensure that our content remains reliable and trustworthy.
