Acetyl Tripeptide-30 Citrulline is a synthetic peptide (known under the name Peptide AC29 with sequence Lys-α-Asp-Ile-Citrulline) that prevents the degradation of extracellular matrix components through the inhibition of MMP (metalloproteinase) enzymes.
An In Vitro study was conducted to evaluate the inhibition of metalloproteinases (MMPs) by Acetyl Tripeptide-30 Citrulline. It has been tested with several metalloproteinases to check the selectivity and effectiveness of Peptide AC29 against MMPs. An Inhibition of MMP activity was calculated using fluorescence released by gelatin (denatured collagen).
Results revealed that Acetyl Tripeptide-30 Citrulline completely inhibits MMP-2 activity, which is responsible for the degradation of type I collagen fibers, the most abundant type of collagen in the dermis. It has also been shown to inhibit the activity of MMP-9 by 63.1%, and MMP-1 and MMP-3 by 35% to 40%.
Preserving skin's structural proteins and extracellular matrix (ECM) components, Acetyl Tripeptide-30 Citrulline leaves a significant firming, lifting, and anti-aging effect. Incorporated in high-end skincare products and peptide-based complexes like Vanistryl®, it enhances ECM component regeneration, exposing a supple, youthful, and smoother appearance of the skin.
