Myristoyl Pentapeptide-8 is a synthetic matrikine lipopeptide that mimics the action of cell-adhesion proteins, resulting in a smoother, healthier, and more resilient skin appearance. It has the sequence Myr-Gly-Arg-Lys-Gly-Asp-NH2 and is known under the trade name SymPeptide® 222.
The motif Gly-Arg-Lys-Gly-Asp repeats a part of the type VII collagen sequence (1165-1169). Collagen VII is one of the most important components of the dermal‑epidermal junction (DEJ) and forms anchoring fibrils that interact with type IV collagen and other structural proteins. It is also expressed in the endothelium of blood vessels, including arterioles and venules.
According to the manufacturers cleim, Myristoyl Pentapeptide-8 effectively smooths fine lines and wrinkles and firms the skin by improving dermal cell adhesion and stimulating the production of structural proteins (collagen and keratin). It is especially effective when incorporated into anti-aging applications for the eye area.
In addition, Myristoyl Pentapeptide-8 enhances microvessel integrity, capillary microcirculation, and decongestion, visibly reducing dark circles and the appearance of undereye bags. It is a safe and effective ingredient in anti-aging, eye, and daily care products.
