Acetyl Tetrapeptide-11

Functions
Anti-aging
Firming
Smoothing
CAS Number(s)
928006-88-6
FDA UNII
0R3VC3BV8I
INCI name
Acetyl Tetrapeptide-11

Today older people are still active and comfortable with their life experiences. But one sign of aging is still undesirable: pale skin. Manufacturers of body care products offer numerous anti-aging products that are specially tailored to the needs of mature skin.

Laboratoires Sérobiologiques, the division of Cognis Care Chemicals specializing in cosmetic active ingredients, has therefore developed Acetyl Tetrapeptide-11, an active peptide with the sequence Ac-Pro-Pro-Tyr-Leu, that inhibits the effects of skin aging. It specifically targets the epidermis, which thins with age, becomes more fragile, and loses its radiance. Acetyl Tetrapeptide-11 acts on the two components of the epidermis that are mainly responsible for its cohesion, strengthening the skin's structure and giving it a smooth, youthful appearance.

The skin aging process is determined by two molecules:

  1. Syndecan-1 is a small proteoglycan whose production decreases with age, thereby impairing epidermal cohesion.
  2. Collagen XVII is a protein found in hemidesmosomes - microscopic, punctiform adhesive complexes that influence adhesion between the epidermis and the dermo-epidermal junction.

Acetyl Tetrapeptide-11 improves the skin's elasticity and cohesion, among other things, by stimulating the synthesis of Syndecan-1 and Collagen XVII. It reinforces the cohesion of the epidermis and enhances adhesion between the dermis and the dermal-epidermal junction—the result: more elastic, firmer skin with a refined skin texture.

Efficacy was demonstrated in a panel of retirees aged 65 or older. Their skin now reflects their inner strength; it expresses their joy in life and their pride: aging, yes, but with beauty and grace. Acetyl Tetrapeptide-11 is suitable for use in anti-aging face creams and care products for mature skin.

Synonyms
SYNIORAGE™ LS 9748
SYNIORAGE™ PW LS 9847
Changed

References

Ectopic expression of syndecan-1 in basal epidermis affects keratinocyte proliferation and wound re-epithelialization
Author(s):
, , , , ,
PMID:
17625591
DOI:
10.1038/sj.jid.5700967
Syndecan-1 shedding by meprin β impairs keratinocyte adhesion and differentiation in hyperkeratosis
Author(s):
, , , , , , , , , , ,
PMID:
34508852
DOI:
10.1016/j.matbio.2021.08.002
Targeting the stem cell niche: role of collagen XVII in skin aging and wound repair
Author(s):
, , , , , , ,
PMID:
36185608
DOI:
10.7150/thno.78016
Collagen XVII deficiency alters epidermal patterning
Author(s):
, , , , , , , , , , ,
PMID:
35145203
DOI:
10.1038/s41374-022-00738-2
Topical peptides as cosmeceuticals
Author(s):
, ,
PMID:
27451932
DOI:
10.4103/0378-6323.186500