Acetyl Hexapeptide-37 (known under the trade name Diffuporine™) is a synthetic peptide found by combinatorial peptide screening technology. Scientists from Lipotec S.A. monitored human keratinocyte cells treated with peptides that can produce luminescence when in contact with the luciferase.
Among several peptides, Acetyl Hexapeptide-37 with the sequence (Ac-L-Ser-L-Pro-L-Ala-Gly-Gly-L-Pro-NH2) showed promising results in increasing expression of the human AQP3 (Aquaporin-3) gene and boosting its production up to twice. Increased Aquaporin-3 levels enhance water flux from deeper skin layers to the Stratum Corneum, thereby improving skin hydration, keratinocyte protection, and viability.
In addition to adequate skin hydration, Acetyl Hexapeptide-37 exhibits anti-aging effects, including beneficial actions on keratinocytes and fibroblasts. It promotes keratinocyte cell proliferation, improving skin barrier function and reducing transdermal moisture loss. In addition, Diffuporine™ increases cell viability after cold, dry, or other extreme conditions.
Applied topically, Acetyl Hexapeptide-37 stimulates dermal fibroblasts and enhances Collagen type 1 production, improving skin smoothness, firmness, and elasticity. It is a multifunctional anti-aging peptide that moisturizes, revitalizes, and rejuvenates the skin, revealing a fresh, healthy, youthful appearance.
