Acetyl Tripeptide-54 Amide is a low molecular weight lipo-peptide derived from Adiponectin, an adipose-tissue-specific releasing adipokine. Its sequence is Ac-Phe-Thr-Tyr-NH2 (corresponds to 183-185 positions), and it is known under the trade name Adiponin™. Adiponectin circulates throughout the human body, suppressing not only inflammatory reactions and carcinogenic metastasis but also promoting skin regeneration, moisturization, and wrinkle reduction.
Adiponectin facilitates the proliferation of keratinocytes and fibroblasts, induces the generation of extracellular matrix (ECM) components like collagen, ceramides, and hyaluronic acid, and promotes the expression of filaggrin. Increased filaggrin levels strengthen the skin barrier and maintain skin moisture by boosting the production of natural moisturizing factors (NMFs), including profilaggrin, involucrin, and PCA.
According to the manufacturer's claims, Acetyl Tripeptide-54 Amide helps repair damaged skin, reduces fibrosis, lessens wrinkles, replenishes the dermal barrier, and moisturizes. It also improves skin elasticity by increasing the production of extracellular matrix proteins and glycosaminoglycans in the dermis.
In addition, Acetyl Tripeptide-54 Amide enhances skin renewal by promoting keratinocyte proliferation, resulting in a fresher, more uniform, and healthier appearance. It is a safe and effective ingredient, usually used in 1-5% concentrations.
