Acetyl Tetrapeptide-9

Functions
Firming
Smoothing
Anti-aging
CAS Number(s)
928006-50-2
FDA UNII
VMO8OOD3V0
INCI name
Acetyl Tetrapeptide-9

Acetyl Tetrapeptide-9 is a synthetic matrikine peptide that mimics Lumican's function and regulates fibroblast activity. The ingredient stimulates the skin's natural regenerative mechanisms, so it not only looks young but also feels young. The peptides' sequence is Ac-Gln-Asp-Val-His-OH.

The proteoglycans - small protein-sugar complexes - are of central importance for the effective organization of collagen fibers, and thus the extracellular matrix. Lumican is one of those proteoglycans that bind to collagen, connecting its molecules and decreasing the gap between them, and forming functional fibers.

Scientific studies showed that the natural synthesis of Lumican declines with age. Acetyl Tetrapeptide-9 exerts a unique anti-aging effect by modulating the metabolism of a specific proteoglycan, Lumican, to improve the skin's firmness and suppleness. Lumican plays a significant role: it ensures optimal stability of the extracellular matrix, both by facilitating the synthesis of collagen fibrils and their organization into functional fiber supports.

Binding to specific receptors on fibroblasts' membranes, Acetyl Tetrapeptide-9 boosts the production of Lumican and Collagen type 1, leaving a scientifically proven skin regeneration and fiber reorganization effect. A clinical study has also confirmed that skin is thicker and firmer after four months of treatment with a preparation containing this peptide.

Acetyl Tetrapeptide-9 is a peptide designed to optimize the functionality of collagen fibers, an excellent ingredient for anti-aging applications. It enables a unique mechanism of action that leads to a firm anchoring of the collagen fibrils and a better way to restore the skin's youthful appearance. Consumers report looking and feeling younger, and it is a safe, functional, and effective weapon against skin aging.

Synonyms
Dermican™ PW LS 9838
Dermican™ LS 9837
Changed

References

Lumican, a small leucine-rich proteoglycan
Author(s):
, , , ,
PMID:
18949819
DOI:
10.1002/iub.131
Lumican as a multivalent effector in wound healing
Author(s):
, , ,
PMID:
29501701
DOI:
10.1016/j.addr.2018.02.011
Real World Case Series: Integrated Skincare With Advanced RGN-6 Serum
Author(s):
, , , , , , ,
PMID:
40709746
DOI:
10.1111/jocd.70303
Topical peptides as cosmeceuticals
Author(s):
, ,
PMID:
27451932
DOI:
10.4103/0378-6323.186500