Acetyl Tetrapeptide-2 is a synthetic peptide (sequence Ac-Lys-Asp-Val-Tyr) that repeats a part of the Thymopentin sequence, with proven effects in combating skin sagging. Its sequence is also found in the well-studied Thymopentin-derived Thymopentin (Arg-Lys-Asp-Val-Tyr), known as sh-Pentapeptide-1. It helps to stimulate the skin's structural proteins, such as collagen and elastin, facilitating and improving cohesion between cells and the ECM (extracellular matrix). It is known under the trade name Peptigravity.
Acetyl Tetrapeptide-2 lifts the skin and maintains facial contour by activating FBLN5 and LOXL1, glycoproteins that are fundamental to the proper organization and function of elastin fibers. Together with collagen molecules and elements of the multiprotein complexes, they provide firmness and resistance to the skin.
Increasing collagen and elastin gene expression, Acetyl Tetrapeptide-2 helps prevent the effects of gravity while reorganizing elastin and collagen fibers. It promotes the junction between cells and the ECM, which is essential for communication and the formation of the structural network in the dermis.
Acetyl Tetrapeptide-2 helps reduce skin sagging and dermal disorganization, thereby promoting better dermal restructuring and cohesion. It can be used in anti-aging products to help maintain facial contour and to help reduce sagging in the chest and neck. It is also used in high-end after-weight-loss products.Incorporated in hair care applications, Acetyl Tetrapeptide-2 strengthens hair follicles and prevents hair loss. Studies have shown that, when combined with B vitamins, it improves hair growth and effectively reduces hair loss.
