Progeline™ (Trifluoroacetyl Tripeptide-2; sequence: TFA-Val-Try-Val-OH) is a biomimetic peptide-based complex ingredient that mimics a specific protein, Elafin, responsible for the inhibition of the Elastase enzyme that breaks down elastin. Preserving elastin prevents skin sagging and the development of wrinkles, enabling complete remodeling.
This tripeptide exerts regulatory effects on ECM (extracellular matrix) protein levels and protects the integrity, helping fight the gravitational and mechanical factors of skin aging. By reducing progerin (the damaged form of the dermal Lamin A protein, an aging biomarker), Trifluoroacetyl Tripeptide-2 slows the senescence of skin cells. It visually reduces the appearance of signs of aging and skin maturation, smoothing fine lines and deep wrinkles, and helping fight slackness and sagging.
A series of laboratory and clinical studies have demonstrated the reduction in progerin production. In the laboratory, progerin was quantified in cell lysates of mature skin fibroblasts (that were incubated for 96 hours) using the ELISA method, which showed a significant reduction.
Clinical trials have demonstrated its anti-aging effects, including jawline-lifting action and improvements in skin firmness and elasticity. Progeline™ has an overall satisfaction score of 92%, with consumers agreeing that it helps the skin look firmer, fuller, and denser.
