Biotinoyl Hexapeptide-2 Amide

Functions
Smoothing
Firming
Anti-aging
INCI name
Biotinoyl Hexapeptide-2 Amide

Biotinoyl Hexapeptide-2 Amide is a conjugate of Hexapeptide-2 and biotin (vitamin B7), providing a synergic effect of those superstar ingredients. It is known under the trade name Biotide2000.

The aged dermis contains a low quantity of collagen, which weakens dermal strength and appears as fine wrinkles on all faces. Biotinoyl Hexapeptide-2 Amide directly stimulates collagen production in the fibroblast cells and increases the mass of healthy fibroblasts that form the dermis layer of the skin.

Biotinoyl Hexapeptide-2 Amide increases the expression of genes responsible for collagen production and thickens the dermis layer (as proved by tests on 3D skin models). In addition, it induces the production of cell-communicating proteins, including Collagen-17, Laminin-5, and Integrin-α6.

Biotinoyl Hexapeptide-2 Amide stimulates collagen gene expression in fibroblast and keratinocyte cells, which secrete paracrine factors(FGF2, FGF5, and Interleukins), which activate dermal fibroblast cells to synthesize collagen actively.

Studies with a preparation containing Biotinoyl Hexapeptide-2 Amide showed a reduction in fine wrinkles after 4-5 weeks of application, and the reduction was significant after 9 weeks of application.

Synonyms
Biotide2000

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