Heptapeptide-34 is a synthetic peptide that simulates the binding domain of Transforming Growth Factor-beta1 (TGF-β1), promoting collagen production and accelerating wound healing. Developed at the University of California, it is known in the scientific literature as Cytomodulin-1 (CM-1) and has the sequence Ala-Asn-Val-Ala-Glu-Asn-Ala.
Early studies confirmed that Heptapeptide-34 stimulates dermal fibroblasts, enhancing expression of the Collagen I gene and increasing pro-collagen I production. In skin injury models, it demonstrated efficacy in wound healing.
Later studies revealed its action mechanism. Heptapeptide-34 activates TGFβ and Wnt/β-catenin signaling pathway, while having no or minimal adverse effects typical of TGFβ mimetics, which can promote tumor progression. Moreover, it showed promising results in suppression, reduction of invasion, and inhibition of angiogenesis.
Incorporated into advanced skin care applications, Heptapeptide-34 leaves a firming and anti-aging effect. It is a safe, well-studied, and effective ingredient for topical leave-on anti-aging formulations.
