Palmitoyl Tetrapeptide-94 is a synthetic matrikine lipopeptide that triggers skin repair processes. It has been developed at the University of Manchester using machine learning to identify peptide sequences from ECM proteins with anti-aging properties.
Palmitoyl Tetrapeptide-94 has the sequence Pal-Gly-Pro-Lys-Gly (pal-GPKG), which is a motif (GPKG) repeating multiple times in Collagens type I, II, and other ECM proteins. Like other matrikines, GPKG is a protein fragments that act as a messenger, signaling dermal cells to initiate repair and regeneration.
By simulating damage to structural proteins, Palmitoyl Tetrapeptide-94 triggers the skin's natural repair process and regulates the expression of over 50 key skin proteins. It significantly enhances the deposition of fibrillin-rich microfibrils and collagen, which are critical for skin elasticity and structural integrity.
When combined with Palmitoyl Tetrapeptide-95 in a complex called Pepticology™, it potentiates anti-aging efficacy by reducing key skin photo-aging biomarkers and promoting both epithelial and dermal remodeling. Complex's effectiveness in repairing photo-damage has been compared favorably with that of all-trans-retinoic acid (tretinoin), a gold-standard anti-aging ingredient.Unlike retinoic acid, which is frequently associated with adverse effects such as sensitivity, redness, and irritation, Palmitoyl Tetrapeptide-94 is reported to be well-tolerated and suitable for sensitive skin.
