Palmitoyl Tetrapeptide-94

Functions
Firming
Smoothing
Anti-aging
CAS Number(s)
2770248-46-7
FDA UNII
Z6T2ETB7SH
INCI name
Palmitoyl Tetrapeptide-94
Identifier
CIG-2674
Origin
Synthetic

Palmitoyl Tetrapeptide-94 is a synthetic matrikine lipopeptide that triggers skin repair processes. It has been developed at the University of Manchester using machine learning to identify peptide sequences from ECM proteins with anti-aging properties.

Palmitoyl Tetrapeptide-94 has the sequence Pal-Gly-Pro-Lys-Gly (pal-GPKG), which is a motif (GPKG) repeating multiple times in Collagens type I, II, and other ECM proteins. Like other matrikines, GPKG is a protein fragments that act as a messenger, signaling dermal cells to initiate repair and regeneration.

By simulating damage to structural proteins, Palmitoyl Tetrapeptide-94 triggers the skin's natural repair process and regulates the expression of over 50 key skin proteins. It significantly enhances the deposition of fibrillin-rich microfibrils and collagen, which are critical for skin elasticity and structural integrity.

When combined with Palmitoyl Tetrapeptide-95 in a complex called Pepticology™, it potentiates anti-aging efficacy by reducing key skin photo-aging biomarkers and promoting both epithelial and dermal remodeling. Complex's effectiveness in repairing photo-damage has been compared favorably with that of all-trans-retinoic acid (tretinoin), a gold-standard anti-aging ingredient.

Unlike retinoic acid, which is frequently associated with adverse effects such as sensitivity, redness, and irritation, Palmitoyl Tetrapeptide-94 is reported to be well-tolerated and suitable for sensitive skin.

Synonyms
pal-GPKG
Pal-Gly-Pro-Lys-Gly
Changed

References

  1. Prediction, screening and characterization of novel bioactive tetrapeptide matrikines for skin rejuvenation
    Author(s):
    , , , , , , , , , , , , , , , , , , ,
    PMID:
    38375775
    DOI:
    10.1093/bjd/ljae061
  2. Ability of a novel anti-aging peptide blend to remodel the dermal extracellular matrix
    Author(s):
    , , , , , , ,
    DOI:
    10.1016/j.jaad.2023.07.464
  3. A novel anti-aging peptide blend facilitates epidermal thickening and cell proliferation in aged skin
    Author(s):
    , , , , ,
    DOI:
    10.1016/j.jid.2023.03.744
  4. Promoting Tissue Repair with Natural Cell-Signalling Peptides
    Author(s):
    Journal:
    The University of Manchester (United Kingdom) ProQuest Dissertations & Theses,  2023. 31227645.
  5. Collagen alpha-1(I) chain (P02452 · CO1A1_HUMAN)
    Author(s):
  6. Collagen alpha-1(II) chain (P02458 · CO2A1_HUMAN)
    Author(s):