sh-Polypeptide-4 is a synthetic recombinant analog of human SCF (Stem Cell Factor, Mast Cell Growth Factor, or Kit ligand), a peptide of up to 273 amino acids. It is a cytokine that controls the survival, growth, and differentiation of hematopoietic stem cells.
SCF affects the healing system by activating hematopoietic precursor cells, thereby promoting the repair of cells and tissue. Besides, its expression has also been detected in human keratinocytes in the skin. Moreover, the Stem cell factor is expressed along the migratory routes of melanocytes, allowing a cell to deploy to the proper developmental sites.
sh-Polypeptide-4 restores granulation sphere decline symptoms more rapidly when combined with other cytokines, as this increases the efficiency of hematopoietic cells or keratinocytes and improves the formation of organisms and the delivery of nutritional materials. In addition, studies confirm its chemotactic and mitogen effects on melanocytes, suggesting it as a repigmenting agent for skin and hair care applications.
Scientific tests showed that in the case of Androgenetic alopecia, hair follicle cells secreted 66% less SCF than non-balding cells. sh-Polypeptide-4 promotes hair growth, improving the movement and differentiation of melanin generation factor and the creation of hair growth factor.
Synonyms
Recombinant Human Stem Cell Factor
Recombinant Mast Cell Growth Factor
Recombinant KIT ligand
rh-Polypeptide-4
CG-SCF
Human Oligopeptide-6
rh-Oligopeptide-6
rh-SCF
rh-KITLG
rh-MGF
Changed
References
Recombinant human stem cell factor (kit ligand) promotes human mast cell and melanocyte hyperplasia and functional activation in vivo
Author(s):
Costa JJ, Demetri GD, Harrist TJ, Dvorak AM, Hayes DF, Merica EA, Menchaca DM, Gringeri AJ, Schwartz LB, Galli SJ
PMID:
8676090
DOI:
10.1084/jem.183.6.2681
MGF (KIT ligand) is a chemokinetic factor for melanoblast migration into hair follicles
Author(s):
Jordan SA, Jackson IJ
PMID:
10985860
DOI:
10.1006/dbio.2000.9856
Human recombinant stem-cell factor induces melanocytic hyperplasia in susceptible patients
Author(s):
Grichnik JM, Crawford J, Jimenez F, Kurtzberg J, Buchanan M, Blackwell S, Clark RE, Hitchcock MG
PMID:
7545704
DOI:
10.1016/0190-9622(95)91274-6
Phenotypic reversions at the W/Kit locus mediated by mitotic recombination in mice
Author(s):
De Sepulveda P, Guenet JL, Panthier JJ
PMID:
7565742
DOI:
10.1128/MCB.15.11.5898
SCF/c‐kit signaling is required for cyclic regeneration of the hair pigmentation unit
Author(s):
BOTCHKAREVA NATALIA V., KHLGATIAN MARY, JACK LONGLEY B., BOTCHKAREV VLADIMIR A., GILCHREST BARBARA A.
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