r-(Methionyl sh-Oligopeptide-85) is a synthetic human recombinant peptide, where the initial expression sequence was engineered by appending a methionine initiation codon to the sh‑Oligopeptide‑85 coding region. sh‑Oligopeptide‑85 (retired INCI name) is a human Dyskerin-derived peptide, 55 amino acids long (89-144) from the TruB domain, known in scientific literature as GSE24.2.
Dyskerin is an enzyme that stabilizes RNA molecules and regulates ribosome biogenesis. The DKC1 gene encodes Dyskerin, and mutations in this gene cause X-linked dyskeratosis congenita (X-DC), a premature aging syndrome characterized by irregular dermal pigmentation, nail dystrophy, and mucosal leukoplakia.
Involved in intracellular processes like gene expression regulation, translation, and telomere maintenance, Dyskerin plays an essential role in cell proliferation, DNA protection, and recovery.
When applied topically, r-(Methionyl sh-Oligopeptide-85) packed in biodegradable polymeric PLGA nanoparticles, leaves a significant anti-senescence effect on a cellular level. Encapsulation increased intracellular uptake and bioactivity, including DNA damage rescue and telomerase reactivation.
GSE4, a Small Dyskerin- and GSE24.2-Related Peptide, Induces Telomerase Activity, Cell Proliferation and Reduces DNA Damage, Oxidative Stress and Cell Senescence in Dyskerin Mutant Cells
Author(s):
Iarriccio L, Manguán-García C, Pintado-Berninches L, Mancheño JM, Molina A, Perona R, Sastre L
PMID:
26571381
DOI:
10.1371/journal.pone.0142980
Development of surface modified biodegradable polymeric nanoparticles to deliver GSE24.2 peptide to cells: a promising approach for the treatment of defective telomerase disorders
Expression of the genetic suppressor element 24.2 (GSE24.2) decreases DNA damage and oxidative stress in X-linked dyskeratosis congenita cells
Author(s):
Manguan-Garcia C, Pintado-Berninches L, Carrillo J, Machado-Pinilla R, Sastre L, Pérez-Quilis C, Esmoris I, Gimeno A, García-Giménez JL, Pallardó FV, Perona R
PMID:
24987982
DOI:
10.1371/journal.pone.0101424
Defects in mTR stability and telomerase activity produced by the Dkc1 A353V mutation in dyskeratosis congenita are rescued by a peptide from the dyskerin TruB domain TruB domain
Author(s):
Machado-Pinilla R, Carrillo J, Manguan-Garcia C, Sastre L, Mentzer A, Gu BW, Mason PJ, Perona R
PMID:
22855157
DOI:
10.1007/s12094-012-0865-4
Dyskerin is a component of the Arabidopsis telomerase RNP required for telomere maintenance
Author(s):
Kannan K, Nelson AD, Shippen DE
PMID:
18212040
DOI:
10.1128/MCB.01490-07
Human dyskerin: beyond telomeres
Author(s):
Angrisani Alberto, Vicidomini Rosario, Turano Mimmo, Furia Maria
sh-Oligopeptide-85 SP is a synthetic human recombinant peptide that has the sequence Gly-Phe-Ile-Asn-Leu-Asp-Lys-Pro-Ser-Asn-Pro corresponding to the part of the TruB domain of the human Dyskerin (89-100) protein.
sh-Polypeptide-4 is a synthetic recombinant analog of human SCF (Stem Cell Factor, Mast Cell Growth Factor, or Kit ligand), a peptide of up to 273 amino acids.
Acetyl Tripeptide-30 Citrulline is a synthetic peptide that prevents the degradation of extracellular matrix components through the inhibition of MMP (metalloproteinase) enzymes. It has the sequence Ac-Arg-His-His-Cit.
Palmitoyl sh-Tripeptide-1 Amide is a low molecular weight synthetic recombinant lipo-peptide derived from FGF-1 (Fibroblast Growth Factor-1; sequence part 99-101) that is involved in various cellular processes, including angiogenesis, keratinocyte organization, and wound healing.
Bio-Placenta is a complex composed of synthetic growth factors (mimicking peptide placental growth factors), vitamins, amino acid derivatives, and hyaluronic acid encapsulated in Lecithin nanoparticles that simulate dermal cell growth and proliferation, accelerating skin regeneration and renewal.
sh-Polypeptide-9 is a synthetic recombinant analog of human VEGFA (Vascular Endothelial Growth Factor A). It enhances cell division and migration by increasing the permeability of capillary vessels to serum proteins.
Oligopeptide-73 is a synthetic peptide known under the trade name CG-EPG that triggers the proliferation of keratinocytes and fibroblasts, protects fibroblasts from oxidative stress, and blocks apoptosis.
The skin is facing many kinds of stress, such as aging, mycobacterium and virus attack, UV and infrared light, and recently issued environmental stress, such as pollen, PM2.5, and PM10, including its harmful components polycyclic aromatic hydrocarbons (PAHs) and heavy metals.
Diamond Sirt is a conjugated complex formed by silicon dioxide microspheres covered with aggregated diamonds that stabilize function-sirtuin peptide (Acetyl sh-Pentapeptide-35) for use in anti-aging treatments.
An RCS scavenger helps prevent visible signs of premature aging from pollution and photo-aging. Tripeptide-1 is also a signaling peptide that stimulates the synthesis of extracellular matrix components, primarily collagen, hyaluronic acid, and other GAGs.
