r-(Methionyl sh-Oligopeptide-85) is a synthetic human recombinant peptide, where the initial expression sequence was engineered by appending a methionine initiation codon to the sh‑Oligopeptide‑85 coding region. sh‑Oligopeptide‑85 (retired INCI name) is a human Dyskerin-derived peptide, 55 amino acids long (89-144) from the TruB domain, known in scientific literature as GSE24.2.
Dyskerin is an enzyme that stabilizes RNA molecules and regulates ribosome biogenesis. The DKC1 gene encodes Dyskerin, and mutations in this gene cause X-linked dyskeratosis congenita (X-DC), a premature aging syndrome characterized by irregular dermal pigmentation, nail dystrophy, and mucosal leukoplakia.
Involved in intracellular processes like gene expression regulation, translation, and telomere maintenance, Dyskerin plays an essential role in cell proliferation, DNA protection, and recovery.
When applied topically, r-(Methionyl sh-Oligopeptide-85) packed in biodegradable polymeric PLGA nanoparticles, leaves a significant anti-senescence effect on a cellular level. Encapsulation increased intracellular uptake and bioactivity, including DNA damage rescue and telomerase reactivation.
GSE4, a Small Dyskerin- and GSE24.2-Related Peptide, Induces Telomerase Activity, Cell Proliferation and Reduces DNA Damage, Oxidative Stress and Cell Senescence in Dyskerin Mutant Cells
Author(s):
Iarriccio L, Manguán-García C, Pintado-Berninches L, Mancheño JM, Molina A, Perona R, Sastre L
PMID:
26571381
DOI:
10.1371/journal.pone.0142980
Development of surface modified biodegradable polymeric nanoparticles to deliver GSE24.2 peptide to cells: a promising approach for the treatment of defective telomerase disorders
Expression of the genetic suppressor element 24.2 (GSE24.2) decreases DNA damage and oxidative stress in X-linked dyskeratosis congenita cells
Author(s):
Manguan-Garcia C, Pintado-Berninches L, Carrillo J, Machado-Pinilla R, Sastre L, Pérez-Quilis C, Esmoris I, Gimeno A, García-Giménez JL, Pallardó FV, Perona R
PMID:
24987982
DOI:
10.1371/journal.pone.0101424
Defects in mTR stability and telomerase activity produced by the Dkc1 A353V mutation in dyskeratosis congenita are rescued by a peptide from the dyskerin TruB domain TruB domain
Author(s):
Machado-Pinilla R, Carrillo J, Manguan-Garcia C, Sastre L, Mentzer A, Gu BW, Mason PJ, Perona R
PMID:
22855157
DOI:
10.1007/s12094-012-0865-4
Dyskerin is a component of the Arabidopsis telomerase RNP required for telomere maintenance
Author(s):
Kannan K, Nelson AD, Shippen DE
PMID:
18212040
DOI:
10.1128/MCB.01490-07
Human dyskerin: beyond telomeres
Author(s):
Angrisani Alberto, Vicidomini Rosario, Turano Mimmo, Furia Maria
sh-Oligopeptide-85 SP is a synthetic human recombinant peptide that has the sequence Gly-Phe-Ile-Asn-Leu-Asp-Lys-Pro-Ser-Asn-Pro corresponding to the part of the TruB domain of the human Dyskerin (89-100) protein.
Detoxiquin is a peptide-based complex ingredient that unites Snow mushroom extract with an iron-containing synthetic peptide to protect DNA from reactive radicals, reduce lipid peroxidation, and decrease protein degeneration.
Preventhelia® is a tetrapeptide that fights the detrimental effects of UV radiation on human skin, protecting and repairing DNA, thus preventing premature aging.
Oligopeptide-20 is a synthetic peptide that mimics Somatomedin (Insulin-like growth factor 1; IGF1), involved in normal skin growth, healing, and wound repair.
Coenzyme Q10 is present in dermal cells, where it stimulates ATP (cellular energy molecules) production and protects from oxidative damage (free radicals).
Carnosine is a dipeptide (ß-alanyl-L-histidine) found in the human body. The nature-identical "L" form L-Carnosine is a white odorless powder, soluble in water.
sh-Polypeptide-64 is a synthetic recombinant peptide derived from the human Aquaporin-1 (AQP-1) protein that promotes the transport of water across biological membranes.
Oligopeptide-55 is a synthetic 12 amino acid long peptide that boosts keratinocytes and fibroblasts proliferation and collagen and elastin production improving skin elasticity and resilience.
sh-Polypeptide-4 is a synthetic recombinant analog of human SCF (Stem Cell Factor, Mast Cell Growth Factor, or Kit ligand), a peptide of up to 273 amino acids.
