Authored by: Arthur Ghochikyan, M.D.
Functions
Anti-aging
Regeneration booster
Antioxidant
INCI namer-(Methionyl sh-Oligopeptide-85)
Retired INCI namesh-Oligopeptide-85
r-(Methionyl sh-Oligopeptide-85) is a synthetic human recombinant peptide, where the initial expression sequence was engineered by appending a methionine initiation codon to the sh‑Oligopeptide‑85 coding region. sh‑Oligopeptide‑85 (retired INCI name) is a human Dyskerin-derived peptide, 55 amino acids long (89-144) from the TruB domain, known in scientific literature as GSE24.2.
Dyskerin is an enzyme that stabilizes RNA molecules and regulates ribosome biogenesis. The DKC1 gene encodes Dyskerin, and mutations in this gene cause X-linked dyskeratosis congenita (X-DC), a premature aging syndrome characterized by irregular dermal pigmentation, nail dystrophy, and mucosal leukoplakia.
Involved in intracellular processes like gene expression regulation, translation, and telomere maintenance, Dyskerin plays an essential role in cell proliferation, DNA protection, and recovery.
When applied topically, r-(Methionyl sh-Oligopeptide-85) packed in biodegradable polymeric
PLGA nanoparticles, leaves a significant anti-senescence effect on a cellular level. Encapsulation increased intracellular uptake and bioactivity, including DNA damage rescue and telomerase reactivation.
Synonyms
Dyskerin-peptide
sh-Oligopeptide-85
Methionyl GSE24.2
Small Dyskerin
MGFINLDKPSNPSSHEWAWIRRILRVEKTGHSGTLDPKVTGCLIVCIERATRLVK
References
GSE4, a Small Dyskerin- and GSE24.2-Related Peptide, Induces Telomerase Activity, Cell Proliferation and Reduces DNA Damage, Oxidative Stress and Cell Senescence in Dyskerin Mutant Cells
Author(s):
Iarriccio L, Manguán-García C, Pintado-Berninches L, Mancheño JM, Molina A, Perona R, Sastre L
DOI:
10.1371/journal.pone.0142980
Development of surface modified biodegradable polymeric nanoparticles to deliver GSE24.2 peptide to cells: a promising approach for the treatment of defective telomerase disorders
Author(s):
Egusquiaguirre SP, Manguán-García C, Pintado-Berninches L, Iarriccio L, Carbajo D, Albericio F, Royo M, Pedraz JL, Hernández RM, Perona R, Igartua M
DOI:
10.1016/j.ejpb.2015.01.028
Expression of the genetic suppressor element 24.2 (GSE24.2) decreases DNA damage and oxidative stress in X-linked dyskeratosis congenita cells
Author(s):
Manguan-Garcia C, Pintado-Berninches L, Carrillo J, Machado-Pinilla R, Sastre L, Pérez-Quilis C, Esmoris I, Gimeno A, García-Giménez JL, Pallardó FV, Perona R
DOI:
10.1371/journal.pone.0101424
Defects in mTR stability and telomerase activity produced by the Dkc1 A353V mutation in dyskeratosis congenita are rescued by a peptide from the dyskerin TruB domain TruB domain
Author(s):
Machado-Pinilla R, Carrillo J, Manguan-Garcia C, Sastre L, Mentzer A, Gu BW, Mason PJ, Perona R
DOI:
10.1007/s12094-012-0865-4
Dyskerin is a component of the Arabidopsis telomerase RNP required for telomere maintenance
Author(s):
Kannan K, Nelson AD, Shippen DE
Human dyskerin: beyond telomeres
Author(s):
Angrisani Alberto, Vicidomini Rosario, Turano Mimmo, Furia Maria
DOI:
10.1515/hsz-2013-0287
H/ACA ribonucleoprotein complex subunit DKC1 (O60832 · DKC1_HUMAN)
Author(s):
UniProtKB reviewed (Swiss-Prot)
H/ACA ribonucleoprotein complex subunit DKC1 (O60832 · DKC1_HUMAN)
Author(s):
UniProtKB reviewed (Swiss-Prot)
