r-(Methionyl sh-Oligopeptide-85) is a synthetic human recombinant peptide, where the initial expression sequence was engineered by appending a methionine initiation codon to the sh‑Oligopeptide‑85 coding region. sh‑Oligopeptide‑85 (retired INCI name) is a human Dyskerin-derived peptide, 55 amino acids long (89-144) from the TruB domain, known in scientific literature as GSE24.2.
Dyskerin is an enzyme that stabilizes RNA molecules and regulates ribosome biogenesis. The DKC1 gene encodes Dyskerin, and mutations in this gene cause X-linked dyskeratosis congenita (X-DC), a premature aging syndrome characterized by irregular dermal pigmentation, nail dystrophy, and mucosal leukoplakia.
Involved in intracellular processes like gene expression regulation, translation, and telomere maintenance, Dyskerin plays an essential role in cell proliferation, DNA protection, and recovery.
When applied topically, r-(Methionyl sh-Oligopeptide-85) packed in biodegradable polymeric PLGA nanoparticles, leaves a significant anti-senescence effect on a cellular level. Encapsulation increased intracellular uptake and bioactivity, including DNA damage rescue and telomerase reactivation.References
- GSE4, a Small Dyskerin- and GSE24.2-Related Peptide, Induces Telomerase Activity, Cell Proliferation and Reduces DNA Damage, Oxidative Stress and Cell Senescence in Dyskerin Mutant CellsPMID:26571381DOI:10.1371/journal.pone.0142980
- Development of surface modified biodegradable polymeric nanoparticles to deliver GSE24.2 peptide to cells: a promising approach for the treatment of defective telomerase disordersPMID:25660910DOI:10.1016/j.ejpb.2015.01.028
- Expression of the genetic suppressor element 24.2 (GSE24.2) decreases DNA damage and oxidative stress in X-linked dyskeratosis congenita cellsPMID:24987982DOI:10.1371/journal.pone.0101424
- Defects in mTR stability and telomerase activity produced by the Dkc1 A353V mutation in dyskeratosis congenita are rescued by a peptide from the dyskerin TruB domain TruB domainPMID:22855157DOI:10.1007/s12094-012-0865-4
- Dyskerin is a component of the Arabidopsis telomerase RNP required for telomere maintenancePMID:18212040DOI:10.1128/MCB.01490-07
- Human dyskerin: beyond telomeresDOI:10.1515/hsz-2013-0287
- H/ACA ribonucleoprotein complex subunit DKC1 (O60832 · DKC1_HUMAN)
- H/ACA ribonucleoprotein complex subunit DKC1 (O60832 · DKC1_HUMAN)
