sh-Oligopeptide-85 SP is a synthetic human recombinant peptide that has the sequence Gly-Phe-Ile-Asn-Leu-Asp-Lys-Pro-Ser-Asn-Pro corresponding to the part of the TruB domain of the human Dyskerin (89-100) protein. In the scientific literature, peptide GSE4 is a smaller fragment of GSE24.2 and is also marketed under the trade name Tectum-11®.
sh-Oligopeptide-85 SP is developed and studied by a research group of the Higher Scientific Research Council (CSIC) that studies diseases characterized by alterations in the natural DNA repair machinery. It increases telomerase activity and reduces DNA damage, oxidative stress, and cell senescence.
When applied topically, sh-Oligopeptide-85 SP, packed in biodegradable polymeric PLGA nanoparticles, promotes the regeneration and renewal of damaged skin and protects epidermal cells. It stabilizes DNA repair and protects against oxidative stress by activating the production of antioxidant enzymes, such as catalase (Cat) and superoxide dismutase (SOD), which eliminate free radicals, including ROS and NOS, from cells.
An in silico study indicated the potential effectiveness of sh-Oligopeptide-85 SP for the treatment of chronic skin inflammatory conditions and diseases, including radiodermitis, pruritic skin lesions, xerosis, and ichthyosis. The anti-inflammatory action of the mouthwash containing this peptide will be evaluated in a clinical trial at Complutense University of Madrid for the symptomatic treatment of oral lichen planus.References
- GSE4, a Small Dyskerin- and GSE24.2-Related Peptide, Induces Telomerase Activity, Cell Proliferation and Reduces DNA Damage, Oxidative Stress and Cell Senescence in Dyskerin Mutant CellsPMID:26571381DOI:10.1371/journal.pone.0142980
- GSE4 peptide suppresses oxidative and telomere deficiencies in ataxia telangiectasia patient cellsPMID:30670828DOI:10.1038/s41418-018-0272-7
- Evidence of telomere attrition and a potential role for DNA damage in systemic sclerosisPMID:35086525DOI:10.1186/s12979-022-00263-2
- Incorporating GSE4 peptide in PEG/hyaluronic acid hydrogels to promote the alveolar epithelial differentiation of mesenchymal stem cellsDOI:10.1016/j.polymer.2023.125861
- Novel Immune-Modulating Peptide to Counteract DNA Damage and Boost Tissue Repair: Advanced Machine Learning Confirmation Over Transcriptomes From 3,250 PatientsDOI:10.54615/2231-7805.143018
- Development and validation of a rapid HPLC method for the quantification of GSE4 peptide in biodegradable PEI-PLGA nanoparticlesPMID:25444543DOI:10.1016/j.jchromb.2014.09.041
- Effectiveness of a Sodium Hyaluronate 0.01% and Sh-Oligopeptide-85 SP Mouthwash for the Treatment of Symptomatic Oral Lichen Planus
- H/ACA ribonucleoprotein complex subunit DKC1 (O60832 · DKC1_HUMAN)
