sh-Polypeptide-5 is a synthetic recombinant peptide, an analog of human TGFβ3 (Transforming Growth Factor β3). It regulates the proliferation, growth, and differentiation of skin cells as a potent, multifunctional cytokine, and helps keep the skin young by converting old cells into new ones.
Naturally, TGFβ3 is a signaling cytokine secreted in response to bleeding or skin damage. sh-Polypeptide-5 promotes regenerative processes, accelerates wound healing, and prevents scar formation. It boosts the production of extracellular matrix (ECM) proteins, including collagens I, III, IV, and V, elastin, fibronectin, and thrombospondin.
Improving the organization of structural proteins (collagen and elastin), sh-Polypeptide-5 enhances dermal cell adhesion to the matrix, leaving a significant smoothing, firming, and anti-aging effect. In addition, it transduces signals to other cytokines involved in skin repair.
sh-Polypeptide-5 works cooperatively with other cytokines to restore injuries and environmental damage. It is a potent and safe ingredient for modern anti-aging applications. Some studies showed that TGFβ3 has protective properties against tumorigenesis. However, any growth factor-mimicking peptide should be used with caution, as GFs are correlated with tumorigenesis or progression.
