Palmitoyl Tetrapeptide-72 Amide is a synthetic lipo-peptide with the sequence Pal-His-Tyr-Arg-Ala-NH2 that boosts expression and production of Mohawk, a homeodomain protein abundantly expressed in the young skin and actively involved in the regeneration of EMC components and connective tissue in different parts of the body. It is known under the trade name Skinarch™.
According to the manufacturer, Palmitoyl Tetrapeptide-72 Amide increases Mohawk production, consequently promoting the expression and production of different types of collagen. In addition, it enhances gene expression responsible for synthesizing extracellular matrix (ECM) components and downregulates genes encoding enzymes that degrade ECM structural proteins.
Besides boosting collagen synthesis, Palmitoyl Tetrapeptide-72 Amide enhances its density, organization, and fibril thickness. Applied topically, it exhibits wrinkle-smoothing, rejuvenating, and anti-aging properties, as demonstrated by the manufacturer's in vivo studies.
