sh-Polypeptide-40

Functions
Hydrating
Soothing
Anti-inflammatory
INCI name
Sh-Polypeptide-40

sh-Polypeptide-40 is a synthetic recombinant human placental lactogen (hPL) hormone analog peptide composed of 192 amino acids. hPL is also known as human chorionic somatomammotropin (hCS) or human chorionic somatotropin. 

The structure and function of hPL are more related to those of growth hormone (somatotropin). Human Placental Lactogen prompts amino acid transport, DNA synthesis, and enhances insulin-like growth factor (IGF) production in fibroblasts. 

Applied topically, sh-Polypeptide-40 suppresses the production of inflammatory cytokines, improves skin barrier function, and soothes sensitive skin. In addition, it leaves a long-term moisturizing effect on the skin.

Thanks to its significant anti-inflammatory effect, sh-Polypeptide-40 is used in preparations for atopic dermatitis, xerosis, and dry, itchy skin.
Synonyms
Clairesome-AI
Placental Lactogen
Chorionic Somatomammotropin
Chorionic Somatotropin
Changed

References

Expression and purification of human placenta lactogen in Escherichia coli
Author(s):
, , ,
DOI:
10.1016/j.pep.2005.08.019
Purification and Bioactivity of Placental Lactogen from Water Buffalo, Bubalus bubalis
Author(s):
, , , ,
DOI:
10.17582/journal.pjz/2017.49.6.2307.2312
Placental lactogen-binding sites in isolated fetal fibroblasts: characterization, processing, and regulation
Author(s):
,
PMID:
8389282
DOI:
10.1210/endo.132.6.8389282