Functions
Anti-inflammatory
Soothing
INCI name
Palmitoyl sh-Tetrapeptide-2 Amide
Origin
Synthetic
Palmitoyl sh-Tetrapeptide-2 Amide is a lipo-peptide that inhibits Interleukin-1R, an inflammatory cytokine receptor, soothing skin irritation and acting as an anti-inflammatory agent. It has the sequence Pal-Lys‑Asn‑Val‑Arg-NH2, which corresponds to the 531-534 fragment of the human Interleukin-1 receptor type 1.
According to the manufacturer, Palmitoyl sh-Tetrapeptide-2 Amide also helps fight hypersensitivity and skin allergies. It is known under the trade name Ilonerin™.
See also
Synonyms
Ilonerin™
Changed
References
A Critical Role of the IL-1β-IL-1R Signaling Pathway in Skin Inflammation and Psoriasis Pathogenesis
PMID:
30120937
DOI:
10.1016/j.jid.2018.07.025
In-vivo extravasation induces the expression of interleukin 1 receptor type 1 in human neutrophils
PMID:
22385245
DOI:
10.1111/j.1365-2249.2011.04548.x
Interleukin-1 receptor type 1 (P14778 · IL1R1_HUMAN)
