Authored by: Arthur Ghochikyan, M.D.
Functions
Anti-inflammatory
Soothing
INCI namePalmitoyl Sh-Tripeptide-2 Amide
Palmitoyl sh-Tripeptide-2 Amide is a low molecular weight lipo-peptide derived from Tumor Necrosis Factor Receptor (TNFR; Tumor necrosis factor receptor superfamily member 1B) that inhibits TNF-α (Tumor Necrosis Factor-α; Tumor Necrosis Factor). It has the sequence Pal-His-Leu-Leu-NH2 and is known under the trade name Tenefrin™.
TNF-α, or Tumor Necrosis Factor, is a proinflammatory cytokine produced in the skin after UVB exposure. It is also involved in inflammatory processes in Psoriasis, and TNF-α antagonists are usually prescribed to those patients.
According to the manufacturer, Palmitoyl sh-Tripeptide-2 Amide acts as an antagonist of TNF-α, an inflammatory factor, and, when applied topically, soothes irritated skin and leaves a noticeable anti-inflammatory effect.
References
TNF-alpha production in the skin
Author(s):
Bashir MM, Sharma MR, Werth VP
DOI:
10.1007/s00403-008-0893-7
Inflammation and Psoriasis: A Comprehensive Review
Author(s):
Man AM, Orăsan MS, Hoteiuc OA, Olănescu-Vaida-Voevod MC, Mocan T
DOI:
10.3390/ijms242216095
Learning From Success and Failure: Biologics for Non-approved Skin Diseases
Author(s):
Speeckaert R, Lambert J, van Geel N
DOI:
10.3389/fimmu.2019.01918
Off-label use of TNF-alpha inhibitors in a dermatological university department: retrospective evaluation of 118 patients
Author(s):
Sand FL, Thomsen SF
Tumor necrosis factor receptor superfamily member 1B (P20333 · TNR1B_HUMAN)
Author(s):
UniProtKB reviewed (Swiss-Prot)
