Palmitoyl sh-Tripeptide-4 Amide is a low molecular weight lipo-peptide (316.3 Da) derived from CD99, a cell membrane antigen-like multifunctional protein that is expressed in human cells. It has the sequence Pal-Leu-Gly-Asp-NH2 (CD99; 54-56) and is also known under the trade name Binterin™.
According to the manufacturer's claims, Palmitoyl sh-Tripeptide-4 Amide mimics anti-inflammatory function and suppresses inflammatory processes, and can soothe inflamed areas effectively and quickly. It is a perfect ingredient for post-laser treatment applications like CO2 fractional laser, fractional RF microneedling, or tattoo removal.
In addition, Palmitoyl sh-Tripeptide-4 Amide suppresses inflammatory responses by inhibiting pro-inflammatory cytokines such as TNF-α and IL-1, blocking cytokine-induced receptor clustering (such as TNFR and IL-1R), and inhibiting NF-kB activation. It suppresses TNF-α-induced adhesions of the leucocytes to endothelial cells.
Palmitoyl sh-Tripeptide-4 Amide soothes irritated skin and relieves discomfort by modulating inflammatory reactions. It prevents skin photoaging by suppressing the UVA-induced breakdown of extracellular matrix proteins in the dermis.By inhibiting angiogenesis, Palmitoyl sh-Tripeptide-4 Amide reduces skin redness, revealing a healthy, uniform, radiant appearance. It is a safe and effective ingredient, and it has proven its safety in numerous repeated-dose toxicity tests.
