Authored by: Arthur Ghochikyan, M.D.
Functions
Soothing
Anti-histamin
Anti-psoriasis
Regeneration booster
INCI namesh-Polypeptide-12
sh-Polypeptide-12 is a synthetic recombinant single-chain peptide, an analog of human Interleukin 4 (IL-4), that acts as an antihistamine or immune-suppressor agent to reduce scratching by inhibiting the autoimmune response. It is known under the trade name CG-IL-4; the former INCI designation was Human Oligopeptide-15 or rh-Oligopeptide-15.
sh-Polypeptide-12 lessens skin irritation on the lower part of the legs, which is generally related to circulatory problems. It is effective against psoriasis, an autoimmune condition in which the immune system produces too many immune cells. IL-4 treatment decreases PASI (Psoriasis Area and Severity Index).
In vivo studies showed that sh-Polypeptide-12 activates and induces the proliferation of dermal fibroblasts, enhances collagen and decorin production, and accelerates wound healing.
Synonyms
rh-Polypeptide-12
CG-IL-4
Human Oligopeptide-15
rh-Oligopeptide-15
References
Human recombinant interleukin-4 induces proliferation and interleukin-6 production by cultured human skin fibroblasts
Author(s):
Feghali CA, Bost KL, Boulware DW, Levy LS
DOI:
10.1016/0090-1229(92)90011-c
Stimulation of sulphated glycosaminoglycan and decorin production in adult dermal fibroblasts by recombinant human interleukin-4
Author(s):
Wegrowski Y, Paltot V, Gillery P, Kalis B, Randoux A, Maquart FX
Recombinant murine interleukin 4 protein therapy for psoriasis in a transgenic VEGF mouse model
Author(s):
Ren X, Li J, Zhou X, Luo X, Huang N, Wang Y, Chen X, Wei Y
Interleukin-4 (IL-4) enhances and soluble interleukin-4 receptor (sIL-4R) inhibits histamine release from peripheral blood basophils and mast cells in vitro and in vivo
Author(s):
Niggemann B, Zuberbier T, Herz U, Enssle K, Wahn U, Renz H
DOI:
10.1080/09629359791802
