Hexacarboxymethyl Dipeptide-12

Functions
Humectant
Barrier enhancer
Anti-aging
Anti-acne
CAS Number(s)
1414380-75-8
FDA UNII
A5CR4WJQ6X
INCI name
Hexacarboxymethyl Dipeptide-12

Hexacarboxymethyl Dipeptide-12 is a peptide derivative that acts as a direct activator of Sirtuin1 (SIRT1). SIRT1 is an NAD+-dependent deacetylase enzyme that regulates cellular metabolism, survival, and lifespan. It deacetylates the target protein FoxO1, initiating cell autophagy.

Activating Sirtuin1 and increasing FoxO1 deacetylation, Hexacarboxymethyl Dipeptide-12 maintains the cell's protective autophagy during cell stress. Its SIRT1 activation power is comparable with that of the superstar ingredient Resveratrol.

Hexacarboxymethyl Dipeptide-12 enhances breakdown and recycles proteins and other components, including organelles, to sustain cellular homeostasis. Increased autophagy rejuvenates cells, prolonging lifespan and slowing aging.

As a result, Hexacarboxymethyl Dipeptide-12 improves the skin's barrier function and water-retaining ability, increasing skin hydration, decreasing transdermal moisture loss, and providing a youthful appearance. It acts as a PCA, a potent natural moisturizing factor (NMF) in the stratum corneum.

Comparative tests showed that a preparation containing 0.05% Hexacarboxymethyl Dipeptide-12 was more effective than the industry standard 2% low molecular weight hyaluronic acid. In addition, it enhances free radical scavenging activity and leaves a noticeable anti-inflammatory effect, reducing acne appearance by up to 65%.

Synonyms
Aquatide

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