X50 Lightening is a vitamin-peptide complex that intelligently lightens and brightens the skin. It is a skin-whitening agent that inhibits tyrosinase's enzymatic activity, helping to reduce dermal pigmentation and even skin tone. The liposomes contain 15% arbutin and 15% sodium ascorbyl phosphate (a vitamin C derivative).
X50 Lightening combines the ITD technology, which binds a peptide (a-MSH antagonist) to the outer layer of the Capsule X50®. This peptide shows an extraordinary affinity for the MC1 receptor on melanocytes; therefore, it selectively interacts with the target cell, initiating internalization of the capsule by endocytosis and delivering the encapsulated active ingredient into the melanocyte cytosol.
In this case, the external peptide acts as a peptidic ligand, directing the capsules to the cell receptor. It also acts as an active function, an antagonist of α-MSH. This peptide is conjugated to the outer layer of the capsule at a concentration of 5%.
Arbutin has been shown to inhibit melanin production in B16 cells induced by α-MSH and to decrease tyrosinase activity in a cell-free system. This suggests that arbutin can be a suitable agent for lightening the skin.Vitamin C, presented in X50 Lightening as sodium ascorbyl phosphate (SAP), has been widely used as a skincare ingredient. It protects the skin, promotes cell turnover, and improves the skin's appearance. Additionally, it is an excellent antioxidant and offers skin-balancing properties to help correct uneven skin tone. SAP is degraded enzymatically in the skin to deliver vitamin C. It acts on melanin production to prevent hyperpigmentation and senile keratosis.
