sh-Nonapeptide-4 is a synthetic recombinant peptide known under the trade name Clodessine, a fragment of the human Klotho protein that activates different Fibroblast Growth Factors (FGF) and is related to longevity. Klotho is considered to be an anti-aging factor.
sh-Nonapeptide-4 inhibits Insulin Growth Factor (IGF) receptors, referring to premature aging, and stimulates the production of Superoxide dismutase and Catalase enzymes, antioxidants that provide a natural defense against reactive species, protecting dermal cells from oxidative stress.
Protecting dermal cells from environmental damaging factors,sh-Nonapeptide-4 also activates DNA repair processes in the skin cells, preventing premature aging, extending cell lifespan, and preserving natural beauty. It improves skin elasticity and visibly reduces wrinkles and pores.
In addition, sh-Nonapeptide-4 increases energy production, enhancing cell metabolism, function, and viability. Incorporated into skin care applications, this peptide effectively fights fine lines and wrinkles, revealing a smoother, fresher, and more youthful appearance.
