Palmitoyl Tripeptide-36

Palmitoyl Tripeptide-36 (Palmitoyl Trilysine) is a synthetic amphiphilic lipo-peptide that exhibits antimicrobial activity. It inhibits the growth of Staphylococcus aureus and other bacteria and fungi. The peptide sequence is Palmitoyl-Lys-Lys-Lys-OH and is known under the trade name DermaPep™ M330.

Scientific studies showed that amphiphilic lipopeltides containing positively charged Lysine chains with 2-5 residues form micelle-like structures with antibacterial properties. Those cationic peptide amphiphiles damage negatively charged bacterial membranes, leading to cell death. They have been shown to be effective against methicillin-resistant Gram-positive and Gram-negative bacteria at very low minimum inhibitory concentrations.

Palmitoyl Trilysine is a classic antibacterial peptide amphiphile with proven antimicrobial and anti-biofilm formation properties. Palmitoyl Tripeptide-36 is a suitable antimicrobial agent for skin care in patients with Atopic Dermatitis (AD). When combined with Azelaic acid, it is used in specialized complexes for acne treatment products.