Functions
Anti-hair-loss
Hair growth stimulator
FDA UNII
S66L9GZ8AV
INCI name
Oligopeptide-41
Identifier
CIG-1822
Origin
Synthetic
Oligopeptide-41 is a synthetic peptide with the sequence Ala-Ser-Ala-Lys-Trp-Thr-His-Asn-Gly-Gly-Glu-Met-Phe that suppresses Dickkopf 1 (DKK-1), which itself acts as a WNT Signaling Pathway Inhibitor. This peptide is also known under the trade name CG-Keramin1.
DKK-1 is involved in pathologic processes resulting in pattern baldness. Inhibiting DKK-1, Oligopeptide-41 preserves hair follicles and prevents hair loss.
In addition, Oligopeptide-41 boosts hair follicle cell proliferation and migration, reduces UV-induced follicular cell apoptosis, and strengthens follicles and hair.
See also
Synonyms
CG-Keramin1
ASAKWTHNGGEMF
Ala-Ser-Ala-Lys-Trp-Thr-His-Asn-Gly-Gly-Glu-Met-Phe
Changed
References
Dickkopf-1: Current knowledge and related diseases
PMID:
30102902
DOI:
10.1016/j.lfs.2018.08.019
088 β-catenin stimulating peptide stimulates the hair growth through the DKK-1 signaling modulation
Dickkopf 1 promotes regression of hair follicles
PMID:
22358062
DOI:
10.1038/jid.2012.24
Dickkopf-1 Expression in Androgenetic Alopecia and Alopecia Areata in Male Patients
PMID:
30640755
DOI:
10.1097/DAD.0000000000001266
