Oligopeptide-34 is a synthetic peptide that decreases melanin synthesis by down-regulation of TRP-1, TRP-2, MITF, and Tyrosinase. It also blocks melanosome assembly and its transfer from melanocytes to keratinocytes, leaving a significant skin-brightening effect. It has the sequence Ile-Trp-Ser-Leu-Asp-Thr-Gln-Tyr-Gly-Gly-Arg-Gly-Asp and is known under the trade name CG-TGP2.
Additionally, Oligopeptide-34 activates the breakdown of melanocyte-stimulating hormone (MSH), a central regulator of tyrosinase enzyme production. Tyrosinase plays a crucial role in the melanin synthesis cascade.
Tests with a preparation containing Oligopeptide-34 showed significant inhibition of melanin synthesis and decreased tyrosinase activity in melanocyte cell lines in a concentration-dependent manner.
By downregulating TH1-type pro-inflammatory cytokines, Oligopeptide-34 reduces dermal lymphocyte proliferation, resulting in a noticeable anti-inflammatory effect. Moreover, it promotes fibroblast division and differentiation, significantly increasing collagen, elastin, and fibronectin levels in the skin's extracellular matrix (ECM).CG-TGP2 is a multifunctional, safe, and effective ingredient used in preparations against hyperpigmentation and anti-aging applications.
