Azelaoyl Bis-Dipeptide-10 (Bipure) is an innovative tetrapeptide obtained by condensation from azelaic acid and two molecules of the Dipeptide-10 (alanine-histidine). Azelaic acid acts as a lipophilic carrier that also enhances antioxidant activity, scavenging free radicals and protecting skin cells from oxidative stress.
Thanks to the presence of two dipeptide molecules, Ala-His, the whole molecule can be considered a tetrapeptide that inhibits the glycation of skin proteins and promotes cell renewal. Alanine-histidine (α-Ala-His) is an isomer of Carnosine (ß-Ala-His), which retards the Maillard reaction, thus impeding protein glycation. Studies show that Dipeptide-10 also exhibits Carnosine-like properties and reduces glycation1.
Glycation of ECM (extracellular matrix) proteins (like collagen) is one of the aging processes in the skin that impairs the structure, distribution, and function of fibers. The molecular structure of Azelaoyl Bis-Dipeptide-10 prevents sugar binding to proteins (glycation), thereby inhibiting the formation of AGEs and preserving skin firmness and elasticity.
Azelaoyl Bis-Dipeptide-10 minimizes the impression of fine lines and wrinkles thanks to the dual action against skin maturation. It is a safe and effective ingredient for anti-aging preparations, delivering a firmer, fresher, and more youthful appearance.
