Copper Biotinoyl Tripeptide-1 is a synthetic complexed peptide derivative with antioxidant, antiglycation, and anti-inflammatory properties. It is a synthetic complex of a Biotinoyl Tripeptide-1 (biotinylated GHK peptide) matrikine with Cu2+, known in scientific literature as Cu(II)-BioGHK. Its individual ancestors, Copper Tripeptide-1 and Biotinoyl Tripeptide-1, used separately or in a band, showed excellent results in skin, scalp, and hair care applications.
The functional efficacy of this Copper Biotinoyl Tripeptide-1 is rooted in the proven biological pathways of its constituent parts. The GHK tripeptide is a well-studied matrikine, a bioactive fragment released from extracellular matrix (ECM) proteins, such as type I collagen and SPARC, during degradation. While Copper Tripeptide-1 (GHK-Cu) acts as a primary antioxidant and regeneration booster, accelerating wound healing and promoting tissue remodeling, Biotinoyl Tripeptide-1 serves as a dedicated "hair booster." It strengthens hair anchoring within the follicles, prolongs the anagen (growth) phase, and stimulates the metabolism of follicle cells by upregulating structural proteins like laminin-5 and collagen IV.
Recent studies showed that biotinylation of the GHK peptide doesn't affect its ability to form Cu2+-peptide cations or its antioxidant properties. Moreover, thanks to copper-induced ascorbate oxidation, it demonstrates that the Cu(II)-BioGHK complex possesses high antioxidant activity, effectively suppressing the generation of reactive oxygen species (ROS).
Furthermore, the complex exhibits significant antiglycation properties. By inhibiting the formation of carbonylated species and mitigating the harmful reactive species that lead to protein cross-linking, Copper Biotinoyl Tripeptide-1 functions as a comprehensive anti-aging agent, protecting the dermal cells and ECM proteins from oxidative stress and structural changes.
