Matrixyl 3000 combines two peptides that help to improve the cellular health of the skin cells, specifically the skin’s extracellular matrix.
Tripeptide-1 (GHK peptide) Derivatives
Tripeptide‑1 (GHK) is a small, naturally occurring peptide in human plasma that declines with age. Aging is associated with increased activity of inflammatory, oncogenic, and tissue‑destructive genes, alongside reduced expression of regenerative and reparative pathways.GHK peptide and its derivatives counteract these shifts by promoting repair, regeneration, and protective cellular programs.
Key biological effects of Tripeptide-1 derivatives include:
- Enhancing wound healing and tissue regeneration in skin and hair follicles
- Stimulating collagen, glycosaminoglycan, and decorin synthesis, reinforcing the extracellular matrix
- Promoting angiogenesis and nerve outgrowth
- Activating antioxidant and anti‑inflammatory pathways
- Increasing cellular stemness and trophic factor secretion by mesenchymal stem cells.
On the epigenetic level, GHK derivatives activate or suppress various systems:
- Activation:
- DNA repair
- Antioxidant defenses
- TGF‑β–mediated healing
- Ubiquitin‑proteasome system
- Suppression:
- Fibrinogen synthesis
- Insulin/IGF signaling
- Tumor progression
Aldenine® captures noxious RCS (reactive carbonyl species), which skin cells cannot detoxify by themselves when submitted to sunlight. Plant proteins contained in Aldenine® selectively boost the synthesis of Collagen III.
Thanks to stimulating peptide that promotes anti-aging processes in the follicle, encouraging anchoring of molecules, supporting hair growth, and slowing down premature hair loss.
Bis(Tripeptide-1) Copper Acetate is a copper-containing complex of Tripeptide-1 acetate, a derivative of the famous GHK peptide (Glycyl-L-Histidyl-L-Lysine). Its solution is a clear blueish liquid. Its color results from the presence of copper ions.
Numerous skincare products based on copper-peptide complexes are increasingly finding clinical and cosmeceutical uses. The biological basis for these actions is GHK (Tripeptide-1), a peptide generated during tissue damage with a very high affinity for copper (Cu2+).
Copper Tripeptide-1 Palmitamide is a complex of copper with a synthetic lipopeptide, a modification of the famous GHK peptide (Tripeptide-1) in which the terminal lysine's amino group is acylated with palmitic acid.
Haloxyl™ is a peptide complex based on four biologically active molecules, including matrikine lipopeptides Palmitoyl Tripeptide-1 (Pal-GHK) and Palmitoyl Tetrapeptide-7 (Pal-GQPR), iron chelating N-hydroxysuccinimide (NHS), and a flavonoid chrysin, that eliminates under-eye bags and dark circles.
Active ingredient with boosting and moisturizing long-lasting effect, enhanced by its anti-free radical activity, thus preserving the youthfulness of lips.
Liporeductyl® is a complex ingredient packed in a liposome, consisting of plant extracts, biologically active substances, and a peptide with four specific anticellulite actions.
A peptide-based wax, activates the protein and proteoglycan synthesis, which increases the density of the connective tissue and tangibly firms the lip‘s contours, moisturizes, restructures.
Palmitoyl Tripeptide-1 stimulates fibroblasts and enhances the production of collagen and GAGs, smoothing fine lines and deep wrinkles and improving the water-binding ability and elasticity of the skin.
Several studies in the 90s showed that on the cellular level stretch marks formation process starts with endogenous glucocorticoid (corticosteroids) secretion under influence of stress or hormonal changes during puberty or pregnancy.
An RCS scavenger helps prevent visible signs of premature aging from pollution and photo-aging. Tripeptide-1 is also a signaling peptide that stimulates the synthesis of extracellular matrix components, primarily collagen, hyaluronic acid, and other GAGs.
A ferment extract with two peptides (tripeptide-10 citrulline, tripeptide-1) and two proteins (wheat germ protein, soy protein) that boosts collagen synthesis. Trylagen boosts the synthesis of collagen types I, III, and IV, in order to increase collagen levels which are reduced or lost in the aging process.