Authored by: Arthur Ghochikyan, M.D.
Functions
Botox-like
Smoothing
Regeneration booster
INCI namesh-Pentapeptide-5
sh-Pentapeptide-5 is a synthetic recombinant peptide, an analog of human Leu-Enkephalin that mimics endorphin action and leaves a Botox-like effect. This opioid peptide effectively reduces the appearance of expression lines and deep wrinkles, exposing smoother, younger-looking, and healthier skin.
In addition to its Botox-like action, sh-Pentapeptide-5 also mimics the Epidermal Growth Factor (EGF-like effect), promoting skin's regeneration and repair processes. It revitalizes the skin, improving texture, resilience, and barrier function.
When combined with Potassium Glutathione Isomerized Linoleate, sh-Pentapeptide-5 forms a peptide complex called Peptilift to improve delivery and provide additional benefits such as hydration, detoxification, and antioxidant action. This peptide-based complex is used in many formulations for lifting, smoothing, and anti-aging.
Synonyms
Peptilift
Leucine Enkephalin
Leu-Enkephalin
References
A leu-enkephalin depresses transmission from muscle and skin non-nociceptors to first-order feline spinal neurones
Author(s):
Jankowska E, Schomburg ED
DOI:
10.1111/j.1469-7793.1998.513bk.x
Biomimetic endorphin for wrinkle lifting in a daily cosmetic remedy
Author(s):
Ritamaria Di Lorenzo, Antonietta Bernardi, Federica Forgione, Antonia Sacchi, Sonia Laneri
DOI:
10.35841/aadrsc-6.2.106
In vitro skin penetration and degradation of peptides and their analysis using a kinetic model
Author(s):
Ogiso T, Iwaki M, Tanino T, Yono A, Ito A
Leucine-enkephalin promotes wound repair through the regulation of hemidesmosome dynamics and matrix metalloprotease
Author(s):
Yang DJ, Lee KS, Ko CM, Moh SH, Song J, Hur LC, Cheon YW, Yang SH, Choi YH, Kim KW
DOI:
10.1016/j.peptides.2015.12.010
Regulated proenkephalin expression in human skin and cultured skin cells
Author(s):
Slominski AT, Zmijewski MA, Zbytek B, Brozyna AA, Granese J, Pisarchik A, Szczesniewski A, Tobin DJ
Localization of enkephalin immunoreactivity in diverse tissues and cells of the developing and adult rat
Author(s):
Zagon IS, Rhodes RE, McLaughlin PJ
