Tripeptide-41 is a synthetic peptide (sequence Phe-Trp-Tyr) known under the trade name CG-Lipoxin (Lipoxygenase) that delays the accumulation of lipids in the adipocyte and promotes their breakdown into fatty acids. It blocks the action of linoleic acid, which promotes lipid accumulation.
By activating the nuclear transcription factor NF-kB, Tripeptide-41 stimulates the production of tumor necrosis factor α (TNFα), a cytokine that can trigger lipolysis. According to manufacturers' claims, it also lessens C/EBP, which is responsible for adipocyte differentiation (bound to PPARγ contributes to adipose tissue hypertrophy).
In adipocytes (fat cells), Tripeptide-41 increases cAMP levels, initiating lipolysis by promoting triglyceride hydrolysis. Thanks to the lipolytic effect, it stimulates the conversion of triacylglycerides into glycerin and fatty acids and their release from the adipocyte into the intercellular space. As a result, adipocytes (fat cells) shrink.
The manufacturer's clinical study showed that a topical emulsion containing 5% Tripeptide‑41, applied over 8 weeks, reduced abdominal circumference by ~5 cm in one subject. Additional small-scale tests showed reductions in flank and thigh circumference.Tripeptide-41 is an effective topical lipolytic agent for slimming and anti-cellulite applications. It is used as part of lipolytic cocktails to correct body contours. Usually used in concentration: 5–7% in topical emulsions, gels, or creams.
