rh-Polypeptide-13 (sh-Polypeptide-13), also known under the trade name CG-Noggin (former designation Human Oligopeptide-18; rh-Oligopeptide-18), is a synthetic single-chain recombinant polypeptide that promotes hair growth while inhibiting its depigmentation. It was specially developed to strengthen and stimulate hair follicles.
In addition, rh-Polypeptide-13 enhances blood circulation in the scalp, revitalizing hair follicles. CG-Noggin is an antagonist of BMP4 (Bone Morphogenetic Protein 4) that inhibits hair follicle development.
So, CG-Noggin stimulates hair placode formation. Additionally, it significantly enhances epidermal thickness and cell proliferation. Scientific studies have shown that CG-Noggin stimulates hair follicle development in embryonic skin organ culture.
It is a safe and effective ingredient against hair loss and depigmentation (white hair). CG-Noggin is used in high-end hair, lash, and eyebrow care products.
Synonyms
sh-Polypeptide-13
CG-Noggin
Human Oligopeptide-18
rh-Oligopeptide-18
Human Noggin
Changed
References
Regeneration of fat cells from myofibroblasts during wound healing
Author(s):
Plikus MV et al
PMID:
28059714
DOI:
10.1126/science.aai8792
BMP-signaling regulates the generation of hair-cells
Author(s):
Pujades C, Kamaid A, Alsina B, Giraldez F
PMID:
16458882
DOI:
10.1016/j.ydbio.2006.01.001
Noggin is required for induction of the hair follicle growth phase in postnatal skin
Author(s):
Botchkarev Vladimir A., Botchkareva Natalia V., Nakamura Motonobu, Huber Otmar, Funa Keiko, Lauster Roland, Paus Ralf, Gilchrest Barbara A.
DOI:
10.1096/fj.01-0207com
Expression characteristics of BMP2, BMPR-IA and Noggin in different stages of hair follicle in yak skin
Author(s):
Song Liang-Li, Cui Yan, Yu Si-Jiu, Liu Peng-Gang, Liu Jun, Yang Xue, He Jun-Feng, Zhang Qian
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Oligopeptide-71 is a synthetic biomimetic peptide that repeats a ligand binding part of a sequence of the EDA1 (Ectodysplasin) protein that attaches to the Ectodysplasin A receptor (EDAR) responsible for the development of the skin of
Decapeptide-10 is a synthetic peptide that boosts the generation of new dermal cells lessening the appearance of fine lines and wrinkles, preventing their formation, and strengthening hair follicles.
Oligopeptide-41 is a synthetic peptide with the sequence Ala-Ser-Ala-Lys-Trp-Thr-His-Asn-Gly-Gly-Glu-Met-Phe that suppresses Dickkopf 1 (DKK-1), which itself acts as a WNT Signaling Pathway Inhibitor.
sh-Polypeptide-31 is a synthetic recombinant peptide that mimics human Insulin-like Growth Factor-2 (IGF-2). The old designation was rh-Polypeptide-31 (rh- prefix means recombinant human).
Palmitoyl Dipeptide-52 is a simple lipopeptide with sequence Pal-Pro-Pro known under the trade name Silverfree™ developed by Sederma. It is a pro-pigmenting peptide that stimulates the repigmentation of hair.
