Authored by: Arthur Ghochikyan, M.D.
Functions
Hair growth stimulator
Hair-coloring
INCI nameRh-Polypeptide-13
rh-Polypeptide-13 (sh-Polypeptide-13), also known under the trade name CG-Noggin (former designation Human Oligopeptide-18; rh-Oligopeptide-18), is a synthetic single-chain recombinant polypeptide that promotes hair growth while inhibiting its depigmentation. It was specially developed to strengthen and stimulate hair follicles.
In addition, rh-Polypeptide-13 enhances blood circulation in the scalp, revitalizing hair follicles. CG-Noggin is an antagonist of BMP4 (Bone Morphogenetic Protein 4) that inhibits hair follicle development.
So, CG-Noggin stimulates hair placode formation. Additionally, it significantly enhances epidermal thickness and cell proliferation. Scientific studies have shown that CG-Noggin stimulates hair follicle development in embryonic skin organ culture.
It is a safe and effective ingredient against hair loss and depigmentation (white hair). CG-Noggin is used in high-end hair, lash, and eyebrow care products.
Synonyms
sh-Polypeptide-13
CG-Noggin
Human Oligopeptide-18
rh-Oligopeptide-18
Human Noggin
References
Regeneration of fat cells from myofibroblasts during wound healing
Author(s):
Plikus MV et al
DOI:
10.1126/science.aai8792
BMP-signaling regulates the generation of hair-cells
Author(s):
Pujades C, Kamaid A, Alsina B, Giraldez F
DOI:
10.1016/j.ydbio.2006.01.001
Noggin is required for induction of the hair follicle growth phase in postnatal skin
Author(s):
Botchkarev Vladimir A., Botchkareva Natalia V., Nakamura Motonobu, Huber Otmar, Funa Keiko, Lauster Roland, Paus Ralf, Gilchrest Barbara A.
DOI:
10.1096/fj.01-0207com
Expression characteristics of BMP2, BMPR-IA and Noggin in different stages of hair follicle in yak skin
Author(s):
Song Liang-Li, Cui Yan, Yu Si-Jiu, Liu Peng-Gang, Liu Jun, Yang Xue, He Jun-Feng, Zhang Qian
DOI:
10.1016/j.ygcen.2017.11.016
