rh-Polypeptide-13 (sh-Polypeptide-13), also known under the trade name CG-Noggin (former designation Human Oligopeptide-18; rh-Oligopeptide-18), is a synthetic single-chain recombinant polypeptide that promotes hair growth while inhibiting its depigmentation. It was specially developed to strengthen and stimulate hair follicles.
In addition, rh-Polypeptide-13 enhances blood circulation in the scalp, revitalizing hair follicles. CG-Noggin is an antagonist of BMP4 (Bone Morphogenetic Protein 4) that inhibits hair follicle development.
So, CG-Noggin stimulates hair placode formation. Additionally, it significantly enhances epidermal thickness and cell proliferation. Scientific studies have shown that CG-Noggin stimulates hair follicle development in embryonic skin organ culture.
It is a safe and effective ingredient against hair loss and depigmentation (white hair). CG-Noggin is used in high-end hair, lash, and eyebrow care products.
Synonyms
sh-Polypeptide-13
CG-Noggin
Human Oligopeptide-18
rh-Oligopeptide-18
Human Noggin
Changed
References
Regeneration of fat cells from myofibroblasts during wound healing
Author(s):
Plikus MV et al
PMID:
28059714
DOI:
10.1126/science.aai8792
BMP-signaling regulates the generation of hair-cells
Author(s):
Pujades C, Kamaid A, Alsina B, Giraldez F
PMID:
16458882
DOI:
10.1016/j.ydbio.2006.01.001
Noggin is required for induction of the hair follicle growth phase in postnatal skin
Author(s):
Botchkarev Vladimir A., Botchkareva Natalia V., Nakamura Motonobu, Huber Otmar, Funa Keiko, Lauster Roland, Paus Ralf, Gilchrest Barbara A.
DOI:
10.1096/fj.01-0207com
Expression characteristics of BMP2, BMPR-IA and Noggin in different stages of hair follicle in yak skin
Author(s):
Song Liang-Li, Cui Yan, Yu Si-Jiu, Liu Peng-Gang, Liu Jun, Yang Xue, He Jun-Feng, Zhang Qian
Decapeptide-20 is a synthetic peptide known under the trade name CG-Promkine that interacts with receptors for the melanocyte-stimulating hormone preventing the loss of pigment by hair keratinocytes.
sh-Polypeptide-62 is a synthetic recombinant peptide, an analog of human Hepatocyte Growth Factor (HGF). It stimulates keratin production, hair growth, and hair pigmentation, and accelerates wound healing and skin regeneration.
Oligopeptide-71 is a synthetic biomimetic peptide that repeats a ligand binding part of a sequence of the EDA1 (Ectodysplasin) protein that attaches to the Ectodysplasin A receptor (EDAR) responsible for the development of the skin of an embryo. It is known under the trade name CG-Edrin.
Palmitoyl Tetrapeptide-20 Amide is a biomimetic lipo-peptide with sequence Pal-His-Phe-Arg-Trp-NH2 that mimics α-MSH (alpha Melanocyte Stimulating Hormone) by binding the MC1-R (melanocortin 1 receptor) and stimulating melanin production.
sh-Oligopeptide-4 is a synthetic recombinant Thymosin-β4 peptide that helps strengthen hair while stimulating hair follicles to produce healthier hair.
Decapeptide-19 is a synthetic peptide with the sequence Ala-Cys-Asp-Gly-Arg-Thr-Gln-Ala-Leu-Cys that inhibits the specific biological activity of TNF-α cytokine and exhibits anti-inflammatory and hair growth-promoting properties. It is known under the trade name CG-Elima.
sh-Polypeptide-9 is a synthetic recombinant analog of human VEGFA (Vascular Endothelial Growth Factor A). It enhances cell division and migration by increasing the permeability of capillary vessels to serum proteins.
Heptapeptide-28 is a synthetic peptide that promotes hair growth inducing follicle cell proliferation and differentiation. This peptide is also known under the trade name CG-Alostop.
