Pentapeptide-3 is a synthetic peptide with the sequence Gly-Pro-Arg-Pro-Ala-NH2, known under the trade name Vialox peptide. It acts as an acetylcholine (ACh) competitive antagonist, blocking the membrane receptors and leaving a curare-like effect.
Curare (tubocurarine) is a natural paralytic agent used in hunting and for therapeutic (anesthesia) purposes by aborigines of Central and South America.
Mimicking curare action at the postsynaptic membrane, Pentapeptide-3 blocks signal transfer from neurons to muscles, functioning as a neuromuscular blocking agent similar to Botox but used in topical applications (needle-free). Blocking acetylcholine receptors (AChR) leaves Sodium channels closed, inhibiting Na+ release at the postsynaptic membrane and preventing muscle contraction.
Pentapeptide-3 smooths expression lines and deep wrinkles by relaxing facial muscles and lessening contractions. It has been extensively tested and is believed to be safe for topical cosmetic applications. It is an effective alternative to Botox® injections for crow’s feet, forehead, and nasolabial fold expression wrinkles.
