Human Adipocyte Conditioned Media Extract

Functions
Firming
Smoothing
Anti-aging
Hair growth stimulator
Anti-hair-loss
Skin whitening agent
INCI name
Human Adipocyte Conditioned Media Extract
Identifier
CIG-2633

Human Adipocyte Conditioned Media Extract obtained from adipose-derived stem cells is a cocktail containing growth factors, extracellular matrix components, and physiologically active substances. It is also known under the trade name ADSC-CM.

Conditioned medium from Adipose-derived Stem Cells (ADSC-CM) stimulates collagen synthesis and fibroblast migration. In addition, it promotes fibroblast transformation to myofibroblasts (more active differentiated forms) independent of TGF-β. As a result, it accelerates wound healing, skin regeneration, and renewal. Thanks to its transforming growth factor beta 1 (TGFβ-1) content, it also leaves a noticeable skin-whitening effect, inhibiting tyrosinase activity and decreasing melanin production.

Human Adipocyte Conditioned Media Extract is produced using sterile freeze-dried technology. ADSC-CM powder is produced in accordance with the strict KFDA stem cell regulations and guidelines.

Human Adipocyte-Conditioned Media Extract is available in powder form and contains several important cell growth factors, including EGF, FGF-β, and TGF-β. ADSC-CM is a valuable, innovative ingredient for advanced anti-aging applications that rejuvenate, refresh, and smooth the skin.

Thanks to its high concentration of cytokines and growth factors, Human Adipocyte Conditioned Media Extract promotes regenerative processes in the hair follicle, effectively combating androgenetic alopecia. Clinical trials showed that a hair care preparation containing ADSC-CM increased hair quantity and density compared with the placebo group. It was also tested for the treatment of pressure ulcers, with promising results.

Synonyms
ADSC-CM

 

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References

  1. Human Adipocyte Conditioned Medium Promotes In Vitro Fibroblast Conversion to Myofibroblasts
    Author(s):
    , , , , ,
    PMID:
    32581231
    DOI:
    10.1038/s41598-020-67175-3
  2. The Effect of Conditioned Media From Human Adipocyte-Derived Mesenchymal Stem Cells on Androgenetic Alopecia After Nonablative Fractional Laser Treatment
    Author(s):
    , , , ,
    PMID:
    32769526
    DOI:
    10.1097/DSS.0000000000002518
  3. Efficacy of combined treatment with human adipose tissue stem cell‐derived exosome‐containing solution and microneedling for facial skin aging: A 12‐week prospective, randomized, split‐face study
    Author(s):
    , , , , , , ,
    DOI:
    10.1111/jocd.15872
  4. Hypoxic ADSC-CM-Loaded Separable Bilayer Micropatterned Dressing Improved Diabetic Wound Healing via Tissue Integration and Immune Modulation
    Author(s):
    , , , , , ,
    PMID:
    40539763
    DOI:
    10.1021/acsami.5c05220
  5. The Basic Mechanism of Hair Growth Stimulation by Adipose-derived Stem Cells and Their Secretory Factors
    Author(s):
    , , , , , , , ,
    PMID:
    28875863
    DOI:
    10.2174/1574888X12666170829161058
  6. Therapeutic Potential of Adipose-Derived Stem Cells and Their Secretome in Reversible Alopecias: A Systematic Review
    Author(s):
    PMID:
    39170092
    DOI:
    10.4103/ijt.ijt_3_21
  7. Therapeutic applications of adipose cell-free derivatives: a review
    Author(s):
    , , , ,
    PMID:
    32698868
    DOI:
    10.1186/s13287-020-01831-3
  8. Topical hADSCs-HA Gel Promotes Skin Regeneration and Angiogenesis in Pressure Ulcers by Paracrine Activating PPARβ/δ Pathway
    Author(s):
    , , , , , ,
    PMID:
    39478872
    DOI:
    10.2147/DDDT.S474628
  9. Whitening Effect of Adipose-Derived Stem Cells: A Critical Role of TGF-BETA.1
    Author(s):
    , , , , , , , , , ,
    DOI:
    10.1248/bpb.31.606