3-O-Ethyl Ascorbic Acid (former designation: Ethyl Ascorbyl Ether) is a white crystalline powder, an ethered derivative of ascorbic acid, one of the most excellent derivatives of Vitamin C so far. It is chemically very stable and a discolored derivative of ascorbic acid, but it can also penetrate the skin and be metabolized by the body as ascorbic acid. So, its effect is better than pure ascorbic acid.
Exhibiting unique dual lipophilic and hydrophilic properties (water- and oil-soluble), 3-O-Ethyl Ascorbic Acid is an excellent ingredient that can be easily incorporated into different skin care applications. The most important thing is that it can easily penetrate the dermis and have a biological effect, while pure ascorbic acid almost does not enter the dermis.
The 3-O-Ethyl Ascorbic Acid is an exemplary option for cosmetic products for multiple benefits:
Excellent whitening effect: inhibits the activity of Tyrosinase by acting on Cu2+
Prevents the synthesis of melanin（≥2%）
Potent antioxidant effect
A stable derivative of ascorbic acid with a lipophilic and hydrophilic structure
Anti-inflammation inhibits the growth of bacteria
It improves the complexion and enhances skin elasticity.
Repairs skin cells and enhances collagen synthesis.
In addition to its beneficial biological effects, 3-O-Ethyl Ascorbic Acid is very convenient for formulation. It is compatible with hydrogels and oleogels and works well with other skin-whitening agents, such as arbutin and niacinamide. Combined with phytocannabinoid cannabigerol, it reduces UV-induced damage and promotes regenerative processes in the skin.
3-O-ethyl-l-ascorbic acid: Characterisation and investigation of single solvent systems for delivery to the skin
Author(s):
Iliopoulos F, Sil BC, Moore DJ, Lucas RA, Lane ME
PMID:
31517290
DOI:
10.1016/j.ijpx.2019.100025
Lipid-Based Gels for Delivery of 3-O-Ethyl L-Ascorbic acid in Topical Applications
Author(s):
Loza-Rodríguez N, Millán-Sánchez A, Mallandrich M, Calpena AC, López O
PMID:
39339223
DOI:
10.3390/pharmaceutics16091187
The anti-melanogenic effects of 3-O-ethyl ascorbic acid via Nrf2-mediated α-MSH inhibition in UVA-irradiated keratinocytes and autophagy induction in melanocytes
Author(s):
Chen SJ, Hseu YC, Gowrisankar YV, Chung YT, Zhang YZ, Way TD, Yang HL
PMID:
34314818
DOI:
10.1016/j.freeradbiomed.2021.07.030
Antioxidant Ability and Stability Studies of 3- O-Ethyl Ascorbic Acid, a Cosmetic Tyrosinase Inhibitor
Author(s):
Liao WC, Huang YT, Lu LP, Huang WY
PMID:
30311899
Proteomic analysis of the combined effects of cannabigerol and 3-O-ethyl ascorbic acid on kinase-dependent signalling in UVB-irradiated human keratinocytes
Author(s):
Gęgotek A, Jarocka-Karpowicz I, Ryšavá A, Žarković N, Skrzydlewska E
Ascorbyl palmitate is the ester of L-ascorbic and palmitic acids. It's a fat- and water-soluble (amphipathic) antioxidant that has an increased shelf life thus used in many formulations.
Like other forms of Vitamin C, Ascorbyl Tetraisopalmitate helps prevent cellular aging by inhibiting the cross-linking of collagen, oxidation of proteins, and lipid peroxidation.
Magnesium ascorbyl phosphate (MAP) is an esterified derivative of Vitamin C. Unlike L-ascorbic acid, which is lipophobic (only water-soluble), has low pH, and unstable, MAP is lipophilic forms of vitamin C, which is stable at neutral pH.
This particular Vitamin C derivative can be used to stimulate collagen repair thus diminishing some of the effects of photo aging. Sodium Ascorbyl Phosphate is also capable of replenishing Vitamin E’s antioxidant capacity.
Vitamin C also known as L-Ascorbic acid plays a crucial role in human skin. It performs a large number of duties to ensure the radiance, firmness, and youthful look of the skin.
Vitamin C Glucoside knew as Ascorbyl-2-Glucoside is a derivative of ascorbic acid combined with glucose. It is a flawless form of vitamin C that showcases all the outstanding benefits of the vitamin for skin well-being.
Tetrahexyldecyl Ascorbate is the tetra-ester of l-ascorbic acid and 2-hexadecenoic acid, which means that Vitamin C conjugated (esterized) with four lipophilic parts of the 2-hexadecenoic version of isopalmitic acid (an i
Vitamin C, chemically known as l-ascorbic acid, has been valued for centuries due to its incredible ability to prevent disease (such as scurvy), and for its important role in many biological functions.
Ascorbyl Dipalmitate is a white crystalline powder, an oil-soluble and stable Vitamin C derivative. It is a diester of L-ascorbic and palmitic acids, also known under the trade name Nikkol CP.
