Sodium Ascorbate

Functions
Antioxidant
CAS Number(s)
134-03-2
EINECS number(s)
205-126-1
FDA UNII
S033EH8359
INCI name
Sodium Ascorbate

Sodium Ascorbate is a sodium salt of L-Ascorbic acid or Vitamin C, a member of a group of food additives called mineral ascorbates. Although it is primarily used in the food processing industry as an antioxidant, preservative, acidity regulator, and vitamin C supplement (E301), Sodium Ascorbate is also a valuable ingredient in personal care applications.

It has been clinically tested for treating various skin conditions and even diseases like melanoma, and has proven effective for its vitamin C-like action and for killing cancer cells. But unfortunately, Sodium ascorbate inherited the weak point of L-Ascorbic acid: instability. In formulations, it should be protected from air and light, which can break down this powerful ingredient. Thus, liposome or another type of encapsulation is crucial for the effectiveness and shelf-life of this ingredient.

Compared with pure L-Ascorbic acid, Sodium Ascorbate has better bioavailability thanks to the presence of Na+ cation. Special proteins, Sodium-dependent Vitamin C Transporters, are responsible for transferring ascorbate anion (vitamin C) into the cell. A higher sodium gradient provides a higher penetration rate.

Like vitamin C, Sodium Ascorbate is a potent antioxidant. In addition, it works well in synergy with other free-radical-scavenging molecules, such as tocopherols (vitamin E), thereby protecting cell membranes, DNA, and other structures from oxidative stress and UV-induced damage. It is an effective treatment for burn-affected skin and striae distensae (parallel striae lying perpendicular to the skin's tension lines).

In addition, sodium Ascorbate exhibits all the beneficial effects of L-Ascorbic acid on the skin, including boosting collagen and elastin production, suppressing melanin synthesis, and enhancing cell metabolism and skin recovery. It is a safe anti-aging ingredient with many benefits for the skin's healthy, smooth, and bright appearance.

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References

Sodium ascorbate (SA) and l-ascorbic acid (AA) as modifiers of burn affected skin - A comparative analysis
Author(s):
, , ,
PMID:
30352326
DOI:
10.1016/j.saa.2018.10.021
Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin
Author(s):
, , , ,
PMID:
25015208
DOI:
10.1016/j.jdermsci.2014.05.011
Final report of the safety assessment of L-Ascorbic Acid, Calcium Ascorbate, Magnesium Ascorbate, Magnesium Ascorbyl Phosphate, Sodium Ascorbate, and Sodium Ascorbyl Phosphate as used in cosmetics
Author(s):
PMID:
16154915
DOI:
10.1080/10915810590953851
Sodium ascorbate inhibits growth via the induction of cell cycle arrest and apoptosis in human malignant melanoma A375.S2 cells
Author(s):
, , , , , ,
PMID:
17119452
DOI:
10.1097/01.cmr.0000232297.99160.9e
Striae Distensae: In Vitro Study and Assessment of Combined Treatment With Sodium Ascorbate and Platelet-Rich Plasma on Fibroblasts
Author(s):
, , , , , , , , , ,
PMID:
33474574
DOI:
10.1007/s00266-020-02100-7
Sodium ascorbate (vitamin C) induces apoptosis in melanoma cells via the down-regulation of transferrin receptor dependent iron uptake
Author(s):
, , , , , , , , , , ,
PMID:
15672419
DOI:
10.1002/jcp.20286