PEG-40 Stearate

Functions
Detergent
Emulsifier
Humectant
Dispersant
Delivery vehicle
Solubilizer
Surfactant
Liposome forming agent
Penetration enhancer
CAS Number(s)
9004-99-3
FDA UNII
ECU18C66Q7
INCI name
Peg-40 Stearate

PEG-40 Stearate is a mix of esters of stearic acid ethoxylated with approximately 40 units of polyoxyethylene glycol. It is a white to light-brown solid that is soluble in water.

PEG-40 Stearate is a multifunctional vegetable-based ingredient used primarily as a lipophilic non-ionic oil-in-water emulsifier (HLB value 17.3) and valuable as a humectant, dispersing agent, solubilizer, and surfactant.

PEG-40 Stearate is a common ingredient in skin, hair, lip, and eye care formulas. Thanks to its increased stability, it is even used in sun care products. It is non-irritating to the eyes and skin.

PEG-40 Stearate is a wetting agent and conditioner used in hand soaps, lotions, creams, masks, shampoos, and decorative cosmetics. Chemically inert with enhanced stability, it's suitable for a wide range of pH and various actives, emulsions, and solid dispersions. It can be used as a thickening agent, which also improves skin feel.

PEG-40 Stearate has been tested as a delivery vehicle for Trans-resveratrol that can inhibit tyrosinase, a crucial enzyme in melanin production. It showed promising results in forming smaller liposomes with improved emulsifying properties, making it a suitable delivery vehicle and penetration enhancer for skin lightening applications.

Manufactured to meet the Kosher for Passover requirements designated by the Orthodox Union (OU). The specifications of PEG-40 Stearate meet the requirements of the National Formulary XVIII.

Synonyms
Polyoxyl 40 Stearate
Polyoxyethylene 40 stearate
PEG-40 Monostearate
Macrogol Ester 2000
Changed

References

Solid dispersions of drugs in polyoxyethylene 40 stearate: dissolution rates and physico-chemical interactions
Author(s):
,
PMID:
42723
DOI:
10.1111/j.2042-7158.1979.tb11596.x
Comparative Study of Glyceryl Behenate or Polyoxyethylene 40 Stearate-Based Lipid Carriers for Trans-Resveratrol Delivery: Development, Characterization and Evaluation of the In Vitro Tyrosinase Inhibition
Author(s):
, , , , ,
PMID:
29404955
DOI:
10.1208/s12249-018-0961-z