Palmitoyl Tetrapeptide-7 (also known as Rigin™; former designation: Palmitoyl Tetrapeptide-3) is a lipopeptide with immunomodulating properties from Sederma designed to mimic DHEA activity and restore cytokine balance to mature skin. The lipo-tetrapeptide with sequence Pal-GQPR (Pal-Gly-Gln-Pro-Arg), a fragment of immunoglobulin G (sequence 224-227), is sometimes referred to as the "youth hormone molecule."
DHEA (Dehydroepiandrosterone) levels decrease with aging, leading to increased interleukin-6 levels. Palmitoyl Tetrapeptide-7 helps skin look younger by correcting this imbalance and reducing the basal and UV-induced secretions of interleukin-6 in the keratinocytes and fibroblasts, just as DHEA does.
In addition, Palmitoyl Tetrapeptide-7 stimulates phagocytosis similar to Tuftsin (another peptide derived from the sequence of human IgG), improving natural defence mechanisms, clearing cellular debris, and removing alien compounds.
Combined with Palmitoyl Tripeptide-1, Rigin is used in Sederma's famous peptide-based complex called Matrixyl 3000. The complex exhibits noticeable anti-aging effects thanks to a balanced blend of biologically active peptides and complementary action, used in many advanced formulations.F.A.Q.
How Palmitoyl Tetrapeptide-7 keeps the skin younger?
Palmitoyl Tetrapeptide-7 reduces Interleukin-6 (IL-6) production by the critical cells keratinocytes and fibroblasts in the skin. Interleukin-6 is a mediator of inflammation that leads to more rapid degradation of the extracellular matrix components, promoting wrinkles formation and lessening firmness and elasticity of the skin.
Reduction of IL-6 and other pro-inflammatory agents, Palmitoyl Tetrapeptide-7, protects extracellular matrix components from degradation, preserving skin's natural youthfulness and boosting its replenishment.
